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Klrg1 Gene Detail
Summary
  • Symbol
    Klrg1
  • Name
    killer cell lectin-like receptor subfamily G, member 1
  • Synonyms
    2F1-Ag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355294
    NCBI Gene: 50928
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122247555-122259792 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355294
 protein coding gene Chr6:122247555-122259841 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031222
 protein coding gene Chr6:125344599-125358207 (-)
A/J MGP_AJ_G0031192
 protein coding gene Chr6:120595761-120607242 (-)
AKR/J MGP_AKRJ_G0031121
 protein coding gene Chr6:123938314-123951320 (-)
BALB/cJ MGP_BALBcJ_G0031201
 protein coding gene Chr6:120284478-120296299 (-)
C3H/HeJ MGP_C3HHeJ_G0030920
 protein coding gene Chr6:123887827-123900671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031660
 protein coding gene Chr6:128625053-128640235 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028819
 protein coding gene Chr6:117199181-117210411 (-)
CAST/EiJ MGP_CASTEiJ_G0030309
 protein coding gene Chr6:124116452-124130595 (-)
CBA/J MGP_CBAJ_G0030884
 protein coding gene Chr6:133658069-133670009 (-)
DBA/2J MGP_DBA2J_G0031040
 protein coding gene Chr6:119519456-119532580 (-)
FVB/NJ MGP_FVBNJ_G0030992
 protein coding gene Chr6:118461728-118473715 (-)
LP/J MGP_LPJ_G0031120
 protein coding gene Chr6:125499121-125511039 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031027
 protein coding gene Chr6:137630735-137643625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031690
 protein coding gene Chr6:123824950-123837053 (-)
PWK/PhJ MGP_PWKPhJ_G0030024
 protein coding gene Chr6:118339654-118352973 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030391
 protein coding gene Chr6:124126833-124138700 (-)



Homology
more
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRG1, killer cell lectin like receptor G1
  • Synonyms
    2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
  • Links
    NCBI Gene ID: 10219
    neXtProt AC: NX_Q96E93
    UniProt: Q96E93

  • Chr Location
    12p13.31; chr12:8950044-9215570 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a null allele have no abnormal phenoptype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50928 NCBI Gene Model | MGI Sequence Detail 12238 C57BL/6J ±  kb
transcript NM_016970 RefSeq | MGI Sequence Detail 1374 C.BKa-Prkdc  
polypeptide O88713 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 63
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:52111 Hanke T, et al., 2F1 antigen, the mouse homolog of the rat mast cell function-associated antigen, is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol. 1998 Dec;28(12):4409-17
  • Latest
    J:333440 Gurram RK, et al., Crosstalk between ILC2s and Th2 cells varies among mouse models. Cell Rep. 2023 Feb 2;42(2):112073
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory