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Pim3 Gene Detail
Summary
  • Symbol
    Pim3
  • Name
    proviral integration site 3
  • Synonyms
    Kid1, KID-1/kinase induced by depolarization, MGC:27707, MGC:37517
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355297
    NCBI Gene: 223775
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:88746397-88749929 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.36 cM
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355297
 protein coding gene Chr15:88746389-88749929 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022210
 protein coding gene Chr15:90023292-90026824 (+)
A/J MGP_AJ_G0022169
 protein coding gene Chr15:86588014-86591546 (+)
AKR/J MGP_AKRJ_G0022144
 protein coding gene Chr15:89148220-89151752 (+)
BALB/cJ MGP_BALBcJ_G0022175
 protein coding gene Chr15:86688020-86691552 (+)
C3H/HeJ MGP_C3HHeJ_G0021945
 protein coding gene Chr15:89133485-89137017 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022620
 protein coding gene Chr15:93292372-93295904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020145
 protein coding gene Chr15:82818721-82822267 (+)
CAST/EiJ MGP_CASTEiJ_G0021467
 protein coding gene Chr15:89917449-89920981 (+)
CBA/J MGP_CBAJ_G0021912
 protein coding gene Chr15:96458436-96461968 (+)
DBA/2J MGP_DBA2J_G0022039
 protein coding gene Chr15:86023805-86027337 (+)
FVB/NJ MGP_FVBNJ_G0022018
 protein coding gene Chr15:85104104-85107636 (+)
LP/J MGP_LPJ_G0022110
 protein coding gene Chr15:90185852-90189384 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022038
 protein coding gene Chr15:100896171-100899703 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022635
 protein coding gene Chr15:89178472-89182004 (+)
PWK/PhJ MGP_PWKPhJ_G0021208
 protein coding gene Chr15:86083225-86086765 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021042
 protein coding gene Chr15:88921917-88925443 (+)
WSB/EiJ MGP_WSBEiJ_G0021516
 protein coding gene Chr15:89666490-89670012 (+)



Homology
more
  • Human Ortholog
    PIM3, Pim-3 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIM3, Pim-3 proto-oncogene, serine/threonine kinase
  • Synonyms
    pim-3
  • Links
    NCBI Gene ID: 415116
    neXtProt AC: NX_Q86V86
    UniProt: Q86V86

  • Chr Location
    chr22:49960768-49964072 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    32 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Pim3
  • Find Mice (IMSR)
    6 strains or lines available
Homozygous null mice are healthy and fertile and do not display any gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    35
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 223775 NCBI Gene Model | MGI Sequence Detail 3533 C57BL/6J ±  kb
transcript NM_145478 RefSeq | MGI Sequence Detail 2419 C57BL/6  
polypeptide P58750 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:3039613
References
more
  • Summaries
    All 59
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:307548 Ebeid DE, et al., PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression. Cells. 2020 Aug 31;9(9):2001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory