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C1s1 Gene Detail
Summary
  • Symbol
    C1s1
  • Name
    complement component 1, s subcomponent 1
  • Synonyms
    C1s
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355312
    NCBI Gene: 50908
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124507304-124519318 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    510 from dbSNP Build 142
  • Strain Annotations
    9
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355312
 protein coding gene Chr6:124507303-124519340 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0031234
 protein coding gene Chr6:122562325-122582803 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031692
 protein coding gene Chr6:131139417-131295963 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030340
 protein coding gene Chr6:126680920-126694248 (-)
CBA/J MGP_CBAJ_G0030918
 protein coding gene Chr6:136321946-136337039 (-)
DBA/2J MGP_DBA2J_G0031074
 protein coding gene Chr6:122028159-122049303 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031725
 protein coding gene Chr6:126355727-126370167 (-)
PWK/PhJ MGP_PWKPhJ_G0030055
 protein coding gene Chr6:120182491-120187763 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030423
 protein coding gene Chr6:126694478-126729742 (-)



Homology
more
  • Human Ortholog
    C1S, complement C1s
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1S, complement C1s
  • Synonyms
    EDSPD2
  • Links
    NCBI Gene ID: 716
    neXtProt AC: NX_P09871
    UniProt: P09871

  • Chr Location
    12p13.31; chr12:6988259-7071032 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C1S associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    4
  • cDNA Data
    80
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038521 Ensembl Gene Model | MGI Sequence Detail 12015 C57BL/6J ±  kb
transcript ENSMUST00000162443 Ensembl | MGI Sequence Detail 2906 Not Applicable  
polypeptide ENSMUSP00000125712 Ensembl | MGI Sequence Detail 694 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    cDNA 80
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1353567, MGI:2141372, MGI:2141399
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
  • Latest
    J:319954 Mortensen SA, et al., Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):986-991
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory