About   Help   FAQ
C1ra Gene Detail
Summary
  • Symbol
    C1ra
  • Name
    complement component 1, r subcomponent A
  • Synonyms
    mC1rA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355313
    NCBI Gene: 50909
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124489580-124500399 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    10
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355313
 protein coding gene Chr6:124489364-124500402 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0031156
 protein coding gene Chr6:126359543-126370480 (+)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0030916
 protein coding gene Chr6:136259060-136272583 (+)
DBA/2J MGP_DBA2J_G0031072
 protein coding gene Chr6:121844580-121862463 (+)
FVB/NJ MGP_FVBNJ_G0031022
 protein coding gene Chr6:120780727-120890643 (+)
LP/J MGP_LPJ_G0031153
 protein coding gene Chr6:127979242-127996737 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031060
 protein coding gene Chr6:140223665-140248625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031723
 protein coding gene Chr6:126207838-126224205 (+)
PWK/PhJ MGP_PWKPhJ_G0030054
 protein coding gene Chr6:120096938-120101492 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029883
 protein coding gene Chr6:124328839-124361680 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    C1R, complement C1r
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1R, complement C1r
  • Synonyms
    EDS8, EDSPD1
  • Links
    NCBI Gene ID: 715
    neXtProt AC: NX_P00736
    UniProt: P00736

  • Chr Location
    12p13.31; chr12:7080214-7092540 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C1R associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    12
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50909 NCBI Gene Model | MGI Sequence Detail 10820 C57BL/6J ±  kb
    transcript NM_023143 RefSeq | MGI Sequence Detail 2762 C57BL/6  
    polypeptide Q8CG16 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141380, MGI:3719032
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:61131 Lawson PR, et al., A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000 Mar;12(3):231-40
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory