About   Help   FAQ
Atoh7 Gene Detail
Summary
  • Symbol
    Atoh7
  • Name
    atonal bHLH transcription factor 7
  • Synonyms
    bHLHa13, Math5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355553
    NCBI Gene: 53404
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62935564-62937059 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.54 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355553
 protein coding gene Chr10:62935430-62937059 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017312
 protein coding gene Chr10:62606305-62606754 (+)
A/J MGP_AJ_G0017290
 protein coding gene Chr10:60657360-60657809 (+)
AKR/J MGP_AKRJ_G0017250
 protein coding gene Chr10:62262330-62262779 (+)
BALB/cJ MGP_BALBcJ_G0017250
 protein coding gene Chr10:60770944-60771393 (+)
C3H/HeJ MGP_C3HHeJ_G0017073
 protein coding gene Chr10:62167403-62167852 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017708
 protein coding gene Chr10:64849774-64850223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015398
 protein coding gene Chr10:57593439-57593888 (+)
CAST/EiJ MGP_CASTEiJ_G0016644
 protein coding gene Chr10:62227732-62228181 (+)
CBA/J MGP_CBAJ_G0017045
 protein coding gene Chr10:67330449-67330898 (+)
DBA/2J MGP_DBA2J_G0017150
 protein coding gene Chr10:59925445-59925894 (+)
FVB/NJ MGP_FVBNJ_G0017144
 protein coding gene Chr10:59202758-59203207 (+)
LP/J MGP_LPJ_G0017224
 protein coding gene Chr10:63010103-63010552 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017172
 protein coding gene Chr10:69466115-69466564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017746
 protein coding gene Chr10:62099910-62100359 (+)
PWK/PhJ MGP_PWKPhJ_G0016427
 protein coding gene Chr10:59813213-59813662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016209
 protein coding gene Chr10:61446614-61447063 (+)
WSB/EiJ MGP_WSBEiJ_G0016708
 protein coding gene Chr10:62054069-62054518 (+)



Homology
more
  • Human Ortholog
    ATOH7, atonal bHLH transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATOH7, atonal bHLH transcription factor 7
  • Synonyms
    bHLHa13, Math5, NCRNA, PHPVAR, RNANC
  • Links
    NCBI Gene ID: 220202
    neXtProt AC: NX_Q8N100
    UniProt: Q8N100

  • Chr Location
    10q21.3; chr10:68230595-68232113 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATOH7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 8 alleles in 12 genetic backgrounds
    24 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired differentiation of retinal ganglion cells resulting in an increase of amacrine cells. Mice show impaired optic nerve formation and one allele shows loss of circadian photoentrainment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    169
  • cDNA Data
    11
  • Literature Summary
    102
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53404 NCBI Gene Model | MGI Sequence Detail 1496 C57BL/6J ±  kb
    transcript NM_016864 RefSeq | MGI Sequence Detail 1496 ZRU/MplStud  
    polypeptide Q9Z2E5 UniProt | EBI | MGI Sequence Detail 149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000004431 transcription factor ATOH7
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032663 Transcription factor ATOH7, basic helix-loop-helix
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 13
      Primer pair 6
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 102
      Gene Ontology 11
      Phenotypes 82
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354243 Stebbins K, et al., Retinal Input Is Required for the Maintenance of Neuronal Laminae in the Ventrolateral Geniculate Nucleus. eNeuro. 2024 Sep;11(9):ENEURO.0022-24.2024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory