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Vti1b Gene Detail
Summary
  • Symbol
    Vti1b
  • Name
    vesicle transport through interaction with t-SNAREs 1B
  • Synonyms
    Vti1-rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855688
    NCBI Gene: 53612
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79202791-79219428 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855688
 protein coding gene Chr12:79202791-79219441 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019880
 protein coding gene Chr12:79436358-79453002 (-)
A/J MGP_AJ_G0019838
 protein coding gene Chr12:76580641-76597271 (-)
AKR/J MGP_AKRJ_G0019813
 protein coding gene Chr12:78654523-78671167 (-)
BALB/cJ MGP_BALBcJ_G0019817
 protein coding gene Chr12:76834997-76851623 (-)
C3H/HeJ MGP_C3HHeJ_G0019623
 protein coding gene Chr12:79130306-79146985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020269
 protein coding gene Chr12:81780730-81801921 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017888
 protein coding gene Chr12:73597436-73614391 (-)
CAST/EiJ MGP_CASTEiJ_G0019173
 protein coding gene Chr12:73964198-73980917 (-)
CBA/J MGP_CBAJ_G0019594
 protein coding gene Chr12:84979637-84996271 (-)
DBA/2J MGP_DBA2J_G0019709
 protein coding gene Chr12:76204147-76220800 (-)
FVB/NJ MGP_FVBNJ_G0019695
 protein coding gene Chr12:75017403-75034052 (-)
LP/J MGP_LPJ_G0019781
 protein coding gene Chr12:79370129-79386775 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019734
 protein coding gene Chr12:88015852-88032626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020304
 protein coding gene Chr12:78171242-78187888 (-)
PWK/PhJ MGP_PWKPhJ_G0018939
 protein coding gene Chr12:70563645-70580367 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018733
 protein coding gene Chr12:72674196-72690818 (-)
WSB/EiJ MGP_WSBEiJ_G0019226
 protein coding gene Chr12:78789611-78806260 (-)



Homology
more
  • Human Ortholog
    VTI1B, vesicle transport through interaction with t-SNAREs 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VTI1B, vesicle transport through interaction with t-SNAREs 1B
  • Synonyms
    v-SNARE, VTI1, VTI1L, VTI1-LIKE, vti1-rp1, VTI2
  • Links
    NCBI Gene ID: 10490
    neXtProt AC: NX_Q9UEU0
    UniProt: Q9UEU0

  • Chr Location
    14q24.1; chr14:67647085-67674820 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
While the majority of homozygous mutant mice are of normal size, some show reduced weight. A portion of these smaller mice died within 6 weeks of life. Liver cysts were identified in some of the mutant mice that were of normal size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    15
  • cDNA Data
    18
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53612 NCBI Gene Model | MGI Sequence Detail 16638 C57BL/6J ±  kb
    transcript NM_016800 RefSeq | MGI Sequence Detail 1296 C57BL/6  
    polypeptide O88384 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017359 vesicle transport through interaction with t-SNAREs homolog 1B
      (term hierarchy)
    • PDB
      1GL2, 2QYW
    • InterPro Domains
      IPR010989 SNARE
      IPR000727 Target SNARE coiled-coil homology domain
      IPR007705 Vesicle transport v-SNARE, N-terminal
      IPR038407 Vesicle transport v-SNARE, N-terminal domain superfamily
    • GlyGen
      O88384 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144935
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
    • Latest
      J:342920 Bollmann C, et al., Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development. Neural Dev. 2022 Nov 22;17(1):12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory