Nono MGI Mouse Gene Detail - MGI:1855692 - non-POU-domain-containing, octamer binding protein

Symbol

Nono
Name

non-POU-domain-containing, octamer binding protein
Synonyms

P54NRB

Feature Type

protein coding gene
IDs

MGI:1855692
NCBI Gene: 53610
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:100473295-100492193 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 44.14 cM
Mapping Data

2 experiments

SNPs within 2kb

384 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855692	protein coding gene	ChrX:100472924-100492197 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035961	protein coding gene	ChrX:97941643-97961559 (+)
A/J	MGP_AJ_G0035946	protein coding gene	ChrX:97940425-97959718 (+)
AKR/J	MGP_AKRJ_G0035862	protein coding gene	ChrX:100755815-100778051 (+)
BALB/cJ	MGP_BALBcJ_G0035929	protein coding gene	ChrX:96689368-96709951 (+)
C3H/HeJ	MGP_C3HHeJ_G0035638	protein coding gene	ChrX:98348100-98368199 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036458	protein coding gene	ChrX:100844060-100865239 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033288	protein coding gene	ChrX:95689431-95707965 (+)
CAST/EiJ	MGP_CASTEiJ_G0034925	protein coding gene	ChrX:82650600-82672591 (+)
CBA/J	MGP_CBAJ_G0035613	protein coding gene	ChrX:103969029-103994562 (+)
DBA/2J	MGP_DBA2J_G0035767	protein coding gene	ChrX:97150643-97169945 (+)
FVB/NJ	MGP_FVBNJ_G0035705	protein coding gene	ChrX:96533982-96553331 (+)
LP/J	MGP_LPJ_G0035857	protein coding gene	ChrX:98896297-98917915 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035740	protein coding gene	ChrX:108516971-108539141 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036485	protein coding gene	ChrX:97638111-97658636 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

NONO, non-POU domain containing octamer binding

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NONO, non-POU domain containing octamer binding
Synonyms

MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114
Links

HGNC:7871

NCBI Gene ID: 4841

neXtProt AC: NX_Q15233

UniProt: Q15233
Chr Location

Xq13.1; chrX:71254814-71301522 (+) GRCh38

MGI Vertebrate Homology

Nono stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NONO
Gene Tree

Nono

Diseases

3 with human NONO associations

				Human Disease	Mouse Models
				cardiomyopathy IDs cardiomyopathy DOID:0050700 ICD10CM:I42 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544
				intellectual disability IDs intellectual disability DOID:1059 NCI:C84392 UMLS_CUI:C0025362
				syndromic X-linked intellectual disability 34 IDs syndromic X-linked intellectual disability 34 DOID:0060817 OMIM:300967 ORDO:466791

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 5 alleles in 4 genetic backgrounds
36 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

113
Endonuclease-mediated

10
Gene trapped

103
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice carrying a gene trap trap allele show shortening of the circadian period under constant dark conditions. Chimeras for some other gene trap alleles may display gastrulation defects. Hemizygous KO in males causes cardiac fibrosis and results in decreased body weight and increased mortality.

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All GO Annotations

45
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

34
cDNA Data

19
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nono

ZFIN nono

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All Sequences

81
RefSeq

8
UniProt

8
CCDS

CCDS30316.1

Ensembl

ENSMUSG00000031311 (Evidence)
NCBI Gene

53610

			Length	Strain/Species	Flank
genomic	53610	NCBI Gene Model \| MGI Sequence Detail	18899	C57BL/6J	± kb
transcript	NM_001426220	RefSeq \| MGI Sequence Detail	2451	C57BL/6
polypeptide	Q99K48	UniProt \| EBI \| MGI Sequence Detail	473	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011320 non-POU domain-containing octamer-binding protein

(term hierarchy)
PDB

2CPJ, 2RS8
InterPro Domains

IPR012975 NOPS

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034552 p54nrb, RNA recognition motif 1

IPR034558 p54nrb, RNA recognition motif 2

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q99K48 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 22

cDNA 19

Primer pair 2

Other 1

Microarray probesets 7

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MGI:2139550, MGI:3034758

Summaries

All 83

Developmental Gene Expression 9

Gene Ontology 16

Phenotypes 21
Earliest

J:24184 Yang YS, et al., NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol. 1993 Sep;13(9):5593-603
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nono:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161667	ChrX:100473260-100473314 (+)	-8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24