Vti1a MGI Mouse Gene Detail - MGI:1855699 - vesicle transport through interaction with t-SNAREs 1A

Symbol

Vti1a
Name

vesicle transport through interaction with t-SNAREs 1A
Synonyms

1110014F16Rik, 1110018K19Rik, 4921537J05Rik, Vti1-rp2

Feature Type

protein coding gene
IDs

MGI:1855699
NCBI Gene: 53611
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr19:55304727-55615741 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.35 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

8879 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855699	protein coding gene	Chr19:55304489-55615893 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025259	protein coding gene	Chr19:55584335-55913949 (+)
A/J	MGP_AJ_G0025235	protein coding gene	Chr19:52856651-53166151 (+)
AKR/J	MGP_AKRJ_G0025204	protein coding gene	Chr19:54524767-54839750 (+)
BALB/cJ	MGP_BALBcJ_G0025230	protein coding gene	Chr19:52927149-53247269 (+)
C3H/HeJ	MGP_C3HHeJ_G0024990	protein coding gene	Chr19:54749315-55068976 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025673	protein coding gene	Chr19:56954893-57279087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023085	protein coding gene	Chr19:51784911-52094562 (+)
CAST/EiJ	MGP_CASTEiJ_G0024455	protein coding gene	Chr19:54741769-55071798 (+)
CBA/J	MGP_CBAJ_G0024970	protein coding gene	Chr19:59755534-60091049 (+)
DBA/2J	MGP_DBA2J_G0025102	protein coding gene	Chr19:52651185-52962680 (+)
FVB/NJ	MGP_FVBNJ_G0025063	protein coding gene	Chr19:52354580-52665136 (+)
LP/J	MGP_LPJ_G0025188	protein coding gene	Chr19:55459388-55778735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025096	protein coding gene	Chr19:59120061-59468435 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025731	protein coding gene	Chr19:54735991-55055132 (+)
PWK/PhJ	MGP_PWKPhJ_G0024203	protein coding gene	Chr19:52583103-52896060 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024006	protein coding gene	Chr19:53402433-53715155 (+)
WSB/EiJ	MGP_WSBEiJ_G0024525	protein coding gene	Chr19:54853425-55178002 (+)

Human Ortholog

VTI1A, vesicle transport through interaction with t-SNAREs 1A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VTI1A, vesicle transport through interaction with t-SNAREs 1A
Synonyms

MMDS3, MVti1, Vti1-rp2, VTI1RP2
Links

HGNC:17792

NCBI Gene ID: 143187

neXtProt AC: NX_Q96AJ9

UniProt: Q96AJ9
Chr Location

10q25.2; chr10:112446988-112855368 (+) GRCh38

MGI Vertebrate Homology

Vti1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VTI1A
Protein SuperFamily

Membrin-2
Gene Tree

Vti1a

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
28 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

2
Gene trapped

48
Targeted

3
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile.

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All GO Annotations

46
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

901
Tissues

58
cDNA Data

16
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vti1a

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All Sequences

99
RefSeq

40
UniProt

5
CCDS

CCDS29910.1, CCDS89416.1, CCDS89417.1

Ensembl

ENSMUSG00000024983 (Evidence)
NCBI Gene

53611

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024983	Ensembl Gene Model \| MGI Sequence Detail	311015	C57BL/6J	± kb
transcript	ENSMUST00000223690	Ensembl \| MGI Sequence Detail	4175	Not Applicable
polypeptide	ENSMUSP00000153629	Ensembl \| MGI Sequence Detail	224	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017358 vesicle transport through interaction with t-SNAREs homolog 1A

(term hierarchy)
PDB

1VCS
InterPro Domains

IPR027027 GOSR2/Membrin/Bos1

IPR010989 SNARE

IPR000727 Target SNARE coiled-coil homology domain

IPR007705 Vesicle transport v-SNARE, N-terminal

IPR038407 Vesicle transport v-SNARE, N-terminal domain superfamily

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 7

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MGI:1915752, MGI:1915845, MGI:1918188

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 16
Earliest

J:45672 Lupashin VV, et al., Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol Biol Cell. 1997 Dec;8(12):2659-76
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vti1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157082	Chr19:55304057-55304068 (+)	-664 bp
Tssr157083	Chr19:55304105-55304109 (+)	-620 bp
Tssr157084	Chr19:55304710-55304737 (+)	-3 bp
Tssr157085	Chr19:55304745-55304799 (+)	45 bp
Tssr5559	Chr19:55306456-55306457 (+)	1,730 bp
Tssr157086	Chr19:55334553-55334580 (+)	29,840 bp
Tssr157087	Chr19:55400922-55400970 (+)	96,219 bp
Tssr157088	Chr19:55413673-55413686 (+)	108,953 bp
Tssr157089	Chr19:55423805-55423812 (+)	119,082 bp
Tssr157090	Chr19:55453206-55453219 (+)	148,486 bp
Tssr157091	Chr19:55453221-55453248 (+)	148,508 bp
Tssr157092	Chr19:55502676-55502687 (+)	197,955 bp
Tssr157093	Chr19:55541240-55541247 (+)	236,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24