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Tlr5 Gene Detail
Summary
  • Symbol
    Tlr5
  • Name
    toll-like receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858171
    NCBI Gene: 53791
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:182782353-182804010 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 86.12 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    676 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858171
 protein coding gene Chr1:182782317-182804010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016899
 protein coding gene Chr1:189626545-189650452 (+)
A/J MGP_AJ_G0016878
 protein coding gene Chr1:181886286-181907919 (+)
AKR/J MGP_AKRJ_G0016843
 protein coding gene Chr1:187283827-187306121 (+)
BALB/cJ MGP_BALBcJ_G0016836
 protein coding gene Chr1:182523025-182544411 (+)
C3H/HeJ MGP_C3HHeJ_G0016660
 protein coding gene Chr1:188101232-188121673 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017299
 protein coding gene Chr1:195713153-195737129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015006
 protein coding gene Chr1:172953475-172974197 (+)
CAST/EiJ MGP_CASTEiJ_G0016242
 protein coding gene Chr1:187466536-187489749 (+)
CBA/J MGP_CBAJ_G0016634
 protein coding gene Chr1:203005382-203026456 (+)
DBA/2J MGP_DBA2J_G0016740
 protein coding gene Chr1:180665930-180687545 (+)
FVB/NJ MGP_FVBNJ_G0016736
 protein coding gene Chr1:178795997-178820157 (+)
LP/J MGP_LPJ_G0016815
 protein coding gene Chr1:190815546-190837818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016768
 protein coding gene Chr1:209971233-209993463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017336
 protein coding gene Chr1:187122520-187144553 (+)
PWK/PhJ MGP_PWKPhJ_G0016030
 protein coding gene Chr1:179856553-179877615 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015806
 protein coding gene Chr1:186072618-186097668 (+)
WSB/EiJ MGP_WSBEiJ_G0016305
 protein coding gene Chr1:187299077-187320529 (+)



Homology
more
  • Human Ortholog
    TLR5, toll like receptor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR5, toll like receptor 5
  • Synonyms
    MELIOS, SLE1, SLEB1, TIL3
  • Links
    NCBI Gene ID: 7100
    neXtProt AC: NX_O60602
    UniProt: O60602

  • Chr Location
    1q41; chr1:223109404-223143292 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human TLR5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene have a generally normal phenotype. However they fail to respond immunologically to purified flagellin and are resistant to infection with Salmonella typhimurium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    29
  • cDNA Data
    12
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079164 Ensembl Gene Model | MGI Sequence Detail 21658 C57BL/6J ±  kb
    transcript ENSMUST00000193687 Ensembl | MGI Sequence Detail 2909 Not Applicable  
    polypeptide ENSMUSP00000141318 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001156 Toll-like receptor 5
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
      IPR017241 Toll-like receptor
    • GlyGen
      Q9JLF7 9 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 12
      Primer pair 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 122
    • Earliest
      J:61532 Sebastiani G, et al., Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics. 2000 Mar 15;64(3):230-40
    • Latest
      J:350736 Alajoleen RM, et al., Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model. Front Immunol. 2024;15:1359534
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory