Usp2 MGI Mouse Gene Detail - MGI:1858178 - ubiquitin specific peptidase 2

Symbol

Usp2
Name

ubiquitin specific peptidase 2
Synonyms

B930035K21Rik, ubp41

Feature Type

protein coding gene
IDs

MGI:1858178
NCBI Gene: 53376
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr9:43978318-44006924 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.53 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

599 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858178	protein coding gene	Chr9:43978318-44006924 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034689	protein coding gene	Chr9:42517204-42548060 (+)
A/J	MGP_AJ_G0034670	protein coding gene	Chr9:41350959-41380300 (+)
AKR/J	MGP_AKRJ_G0034596	protein coding gene	Chr9:42207564-42236105 (+)
BALB/cJ	MGP_BALBcJ_G0034660	protein coding gene	Chr9:41091879-41120923 (+)
C3H/HeJ	MGP_C3HHeJ_G0034372	protein coding gene	Chr9:42661826-42690378 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035183	protein coding gene	Chr9:43797307-43826758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032097	protein coding gene	Chr9:40943544-40972071 (+)
CAST/EiJ	MGP_CASTEiJ_G0033694	protein coding gene	Chr9:42503454-42534002 (+)
CBA/J	MGP_CBAJ_G0034345	protein coding gene	Chr9:45374538-45405983 (+)
DBA/2J	MGP_DBA2J_G0034504	protein coding gene	Chr9:41265834-41294522 (+)
FVB/NJ	MGP_FVBNJ_G0034444	protein coding gene	Chr9:40515331-40543848 (+)
LP/J	MGP_LPJ_G0034584	protein coding gene	Chr9:42823157-42852778 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034487	protein coding gene	Chr9:47254120-47283954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035203	protein coding gene	Chr9:42104466-42133025 (+)
PWK/PhJ	MGP_PWKPhJ_G0033399	protein coding gene	Chr9:41131694-41160083 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033235	protein coding gene	Chr9:42405126-42433686 (+)
WSB/EiJ	MGP_WSBEiJ_G0033807	protein coding gene	Chr9:42142177-42170752 (+)

Human Ortholog

USP2, ubiquitin specific peptidase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP2, ubiquitin specific peptidase 2
Synonyms

UBP41, USP9
Links

HGNC:12618

NCBI Gene ID: 9099

neXtProt AC: NX_O75604

UniProt: O75604
Chr Location

11q23.3; chr11:119355215-119381711 (-) GRCh38

MGI Vertebrate Homology

Usp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: USP2
Gene Tree

Usp2

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Phenotype Summary

15 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Gene trapped

2
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display severely reduced male fertility with defects in sperm motility.

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All GO Annotations

41
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

84
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp2

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All Sequences

90
RefSeq

28
UniProt

3
CCDS

CCDS23094.1, CCDS23095.1

Ensembl

ENSMUSG00000032010 (Evidence)
NCBI Gene

53376

			Length	Strain/Species	Flank
genomic	53376	NCBI Gene Model \| MGI Sequence Detail	28607	C57BL/6J	± kb
transcript	NM_001407818	RefSeq \| MGI Sequence Detail	4067	C57BL/6
polypeptide	O88623	UniProt \| EBI \| MGI Sequence Detail	619	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017158 ubiquitin carboxyl-terminal hydrolase 2

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050185 Ubiquitin carboxyl-terminal hydrolase

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 6

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MGI:2443236

Summaries

All 59

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 19
Earliest

J:78123 Kameya S, et al., Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet. 2002 Aug 1;11(16):1879-86
Latest

J:355215 Kim J, et al., USF2 and TFEB compete in regulating lysosomal and autophagy genes. Nat Commun. 2024 Sep 27;15(1):8334

TSS for Usp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84599	Chr9:43978263-43978285 (+)	-44 bp
Tssr84600	Chr9:43978290-43978321 (+)	-12 bp
Tssr84601	Chr9:43978338-43978356 (+)	29 bp
Tssr84602	Chr9:43978369-43978431 (+)	82 bp
Tssr84603	Chr9:43978436-43978450 (+)	125 bp
Tssr84604	Chr9:43979446-43979462 (+)	1,136 bp
Tssr84605	Chr9:43979500-43979507 (+)	1,186 bp
Tssr84606	Chr9:43980718-43980749 (+)	2,416 bp
Tssr84607	Chr9:43980759-43980775 (+)	2,449 bp
Tssr84608	Chr9:43983493-43983508 (+)	5,183 bp
Tssr84609	Chr9:43987417-43987448 (+)	9,115 bp
Tssr84610	Chr9:43996211-43996230 (+)	17,903 bp
Tssr84611	Chr9:43996241-43996254 (+)	17,930 bp
Tssr84612	Chr9:43996326-43996344 (+)	18,017 bp
Tssr84613	Chr9:43997498-43997499 (+)	19,181 bp
Tssr84614	Chr9:43997503-43997516 (+)	19,192 bp
Tssr84615	Chr9:44000391-44000432 (+)	22,094 bp
Tssr84616	Chr9:44005162-44005182 (+)	26,854 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24