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Folh1 Gene Detail
Summary
  • Symbol
    Folh1
  • Name
    folate hydrolase 1
  • Synonyms
    GCP2, glutamate carboxypeptidase II, mopsm, prostate-specific membrane antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858193
    NCBI Gene: 53320
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:86368185-86425151 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.51 cM, cytoband D1-D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858193
 protein coding gene Chr7:86365733-86425171 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032485
 protein coding gene Chr7:88989853-89055937 (-)
A/J MGP_AJ_G0032459
 protein coding gene Chr7:86908107-86965652 (-)
AKR/J MGP_AKRJ_G0032396
 protein coding gene Chr7:88974332-89032661 (-)
BALB/cJ MGP_BALBcJ_G0032472
 protein coding gene Chr7:86582537-86639791 (-)
C3H/HeJ MGP_C3HHeJ_G0032185
 protein coding gene Chr7:89355005-89416611 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032969
 protein coding gene Chr7:92566995-92622615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029965
 protein coding gene Chr7:89296520-89344588 (-)
CAST/EiJ MGP_CASTEiJ_G0031512
 protein coding gene Chr7:80766443-80829550 (-)
CBA/J MGP_CBAJ_G0032151
 protein coding gene Chr7:95597563-95660417 (-)
DBA/2J MGP_DBA2J_G0032304
 protein coding gene Chr7:85394834-85451195 (-)
FVB/NJ MGP_FVBNJ_G0032261
 protein coding gene Chr7:85266841-85325600 (-)
LP/J MGP_LPJ_G0032393
 protein coding gene Chr7:90268895-90338061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032294
 protein coding gene Chr7:96276563-96360412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032990
 protein coding gene Chr7:88240088-88309044 (-)
PWK/PhJ MGP_PWKPhJ_G0031231
 protein coding gene Chr7:78386185-78445152 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031074
 protein coding gene Chr7:75434276-75494928 (-)
WSB/EiJ MGP_WSBEiJ_G0031629
 protein coding gene Chr7:88866769-88927568 (-)



Homology
more
  • Human Ortholog
    FOLH1, folate hydrolase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOLH1, folate hydrolase 1
  • Synonyms
    FGCP, FOLH, GCP2, GCPII, mGCP, NAALAD1, PSM, PSMA
  • Links
    NCBI Gene ID: 2346
    neXtProt AC: NX_Q04609
    UniProt: Q04609

  • Chr Location
    11p11.12; chr11:49145092-49208638 (-)  GRCh38
  • Human Ortholog
    FOLH1B, folate hydrolase 1B (pseudogene)
  • Synonyms
    FOLH2, FOLHP, PSM, PSMAL, PSMA-LIKE
  • Links
    NCBI Gene ID: 219595
    neXtProt AC: NX_Q9HBA9
    UniProt: Q9HBA9

  • Chr Location
    11q14.3; chr11:89639237-89698718 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FOLH1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in protection from peripheral neuropathy and ischemic brain injury. Homozygotes for a null allele show increased food intake, anxiety-like behavior, smaller sciatic nerve axons, and impaired angiogenesis. Homozygotes for a different null allele show less neuron degeneration and astrocyte damage after traumatic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001773 Ensembl Gene Model | MGI Sequence Detail 56967 C57BL/6J ±  kb
    transcript ENSMUST00000001824 Ensembl | MGI Sequence Detail 3125 Not Applicable  
    polypeptide ENSMUSP00000001824 Ensembl | MGI Sequence Detail 752 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 18

      Microarray probesets 3
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 45
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:346617 Sedlak F, et al., Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. ACS Chem Neurosci. 2024 Feb 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory