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Hnrnpu Gene Detail
Summary
  • Symbol
    Hnrnpu
  • Name
    heterogeneous nuclear ribonucleoprotein U
  • Synonyms
    Hnrpu, scaffold attachment factor A, Sp120
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858195
    NCBI Gene: 51810
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:178148673-178165362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 83.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858195
 protein coding gene Chr1:178148673-178170063 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016855
 protein coding gene Chr1:184609947-184623453 (-)
A/J MGP_AJ_G0016833
 protein coding gene Chr1:177184762-177198114 (-)
AKR/J MGP_AKRJ_G0016799
 protein coding gene Chr1:182465589-182479029 (-)
BALB/cJ MGP_BALBcJ_G0016791
 protein coding gene Chr1:177818361-177831815 (-)
C3H/HeJ MGP_C3HHeJ_G0016616
 protein coding gene Chr1:183198912-183212366 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017255
 protein coding gene Chr1:190614953-190628407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014962
 protein coding gene Chr1:168194356-168207756 (-)
CAST/EiJ MGP_CASTEiJ_G0016197
 protein coding gene Chr1:182483162-182497873 (-)
CBA/J MGP_CBAJ_G0016590
 protein coding gene Chr1:197703333-197716786 (-)
DBA/2J MGP_DBA2J_G0016696
 protein coding gene Chr1:176041851-176055305 (-)
FVB/NJ MGP_FVBNJ_G0016692
 protein coding gene Chr1:174119515-174132969 (-)
LP/J MGP_LPJ_G0016770
 protein coding gene Chr1:185886295-185899811 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016723
 protein coding gene Chr1:204877052-204892903 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017291
 protein coding gene Chr1:182180908-182194362 (-)
PWK/PhJ MGP_PWKPhJ_G0015985
 protein coding gene Chr1:175095760-175109213 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015761
 protein coding gene Chr1:181134318-181149849 (-)
WSB/EiJ MGP_WSBEiJ_G0016260
 protein coding gene Chr1:182403771-182417286 (-)



Homology
more
  • Human Ortholog
    HNRNPU, heterogeneous nuclear ribonucleoprotein U
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPU, heterogeneous nuclear ribonucleoprotein U
  • Synonyms
    DEE54, EIEE54, GRIP120, hnRNP U, HNRNPU-AS1, HNRPU, pp120, SAF-A, SAFA, U21.1
  • Links
    NCBI Gene ID: 3192
    neXtProt AC: NX_Q00839
    UniProt: Q00839

  • Chr Location
    1q44; chr1:244840638-244864560 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hnrnpu mouse models; 1 with human HNRNPU associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display embryonic lethality, delayed embryonic development, and failure of chorioallantoic fusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    173
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    28
  • cDNA Data
    35
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039630 Ensembl Gene Model | MGI Sequence Detail 16690 C57BL/6J ±  kb
    transcript ENSMUST00000037748 Ensembl | MGI Sequence Detail 7640 Not Applicable  
    polypeptide ENSMUSP00000047571 Ensembl | MGI Sequence Detail 800 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000008673 heterogeneous nuclear ribonucleoprotein U
      (term hierarchy)
    • InterPro Domains
      IPR001870 B30.2/SPRY domain
      IPR043136 B30.2/SPRY domain superfamily
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR035778 Heterogeneous nuclear ribonucleoprotein U, SPRY domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR003034 SAP domain
      IPR036361 SAP domain superfamily
      IPR003877 SPRY domain
    • GlyGen
      Q8VEK3 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138082, MGI:2138186, MGI:2138396, MGI:2138400, MGI:2138619, MGI:2138718, MGI:2146028
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 22
      Phenotypes 16
    • Earliest
      J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
    • Latest
      J:358462 Hong SP, et al., Hnrnpu Is Essential for Proper Murine Skin Development. J Invest Dermatol. 2024 Oct 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory