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Plrg1 Gene Detail
Summary
  • Symbol
    Plrg1
  • Name
    pleiotropic regulator 1
  • Synonyms
    Tango4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858197
    NCBI Gene: 53317
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82962845-82979598 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858197
 protein coding gene Chr3:82962829-82979662 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027334
 protein coding gene Chr3:82878850-82896140 (+)
A/J MGP_AJ_G0027298
 protein coding gene Chr3:80149161-80165710 (+)
AKR/J MGP_AKRJ_G0027264
 protein coding gene Chr3:82054837-82073260 (+)
BALB/cJ MGP_BALBcJ_G0027307
 protein coding gene Chr3:80243293-80260385 (+)
C3H/HeJ MGP_C3HHeJ_G0027051
 protein coding gene Chr3:82340890-82357478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027753
 protein coding gene Chr3:85997072-86013653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025106
 protein coding gene Chr3:75868090-75884798 (+)
CAST/EiJ MGP_CASTEiJ_G0026498
 protein coding gene Chr3:82526512-82544498 (+)
CBA/J MGP_CBAJ_G0027026
 protein coding gene Chr3:88903531-88924157 (+)
DBA/2J MGP_DBA2J_G0027162
 protein coding gene Chr3:79692013-79708799 (+)
FVB/NJ MGP_FVBNJ_G0027130
 protein coding gene Chr3:77973622-77990353 (+)
LP/J MGP_LPJ_G0027270
 protein coding gene Chr3:83866327-83883588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027149
 protein coding gene Chr3:95298411-95315727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027811
 protein coding gene Chr3:81851522-81868904 (+)
PWK/PhJ MGP_PWKPhJ_G0026232
 protein coding gene Chr3:79453319-79469463 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026048
 protein coding gene Chr3:81042526-81060905 (+)
WSB/EiJ MGP_WSBEiJ_G0026576
 protein coding gene Chr3:82184954-82203580 (+)



Homology
more
  • Human Ortholog
    PLRG1, pleiotropic regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLRG1, pleiotropic regulator 1
  • Synonyms
    Cwc1, PRL1, PRP46, PRPF46, TANGO4
  • Links
    NCBI Gene ID: 5356
    neXtProt AC: NX_O43660
    UniProt: O43660

  • Chr Location
    4q31.3; chr4:154535005-154550400 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality by E1.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    48
  • cDNA Data
    71
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53317 NCBI Gene Model | MGI Sequence Detail 16754 C57BL/6J ±  kb
    transcript NM_016784 RefSeq | MGI Sequence Detail 1771 C57BL/6  
    polypeptide Q922V4 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139608, MGI:2140075
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory