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Map3k14 Gene Detail
Summary
  • Symbol
    Map3k14
  • Name
    mitogen-activated protein kinase kinase kinase 14
  • Synonyms
    Nik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858204
    NCBI Gene: 53859
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103110590-103158227 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1419 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858204
 protein coding gene Chr11:103110588-103158298 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019261
 protein coding gene Chr11:106277141-106329349 (-)
A/J MGP_AJ_G0019229
 protein coding gene Chr11:101768117-101817407 (-)
AKR/J MGP_AKRJ_G0019198
 protein coding gene Chr11:104902731-104950728 (-)
BALB/cJ MGP_BALBcJ_G0019203
 protein coding gene Chr11:102235256-102283210 (-)
C3H/HeJ MGP_C3HHeJ_G0019012
 protein coding gene Chr11:105132296-105180589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019652
 protein coding gene Chr11:109581695-109629397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017278
 protein coding gene Chr11:99175672-99224023 (-)
CAST/EiJ MGP_CASTEiJ_G0018566
 protein coding gene Chr11:106150823-106198589 (-)
CBA/J MGP_CBAJ_G0018981
 protein coding gene Chr11:114137792-114190386 (-)
DBA/2J MGP_DBA2J_G0019093
 protein coding gene Chr11:101275111-101322919 (-)
FVB/NJ MGP_FVBNJ_G0019083
 protein coding gene Chr11:100818924-100870104 (-)
LP/J MGP_LPJ_G0019162
 protein coding gene Chr11:106786944-106839326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019114
 protein coding gene Chr11:113517931-113566622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019690
 protein coding gene Chr11:105287805-105336344 (-)
PWK/PhJ MGP_PWKPhJ_G0018329
 protein coding gene Chr11:102347846-102397772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018121
 protein coding gene Chr11:105039401-105093041 (-)
WSB/EiJ MGP_WSBEiJ_G0018615
 protein coding gene Chr11:105286385-105338608 (-)



Homology
more
  • Human Ortholog
    MAP3K14, mitogen-activated protein kinase kinase kinase 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K14, mitogen-activated protein kinase kinase kinase 14
  • Synonyms
    FTDCR1B, HS, HSNIK, IMD112, NIK
  • Links
    NCBI Gene ID: 9020
    neXtProt AC: NX_Q99558
    UniProt: Q99558

  • Chr Location
    17q21.31; chr17:45263119-45317029 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Map3k14 mouse models; 1 with human MAP3K14 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 7 alleles in 10 genetic backgrounds
    17 phenotypes from multigenic genotypes
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit deficiencies in cellular and humoral immunity, susceptibility to infections, absence of lymph nodes and Peyer's patches, failure of isotype switching, and inflammation of exocrine organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    108
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53859 NCBI Gene Model | MGI Sequence Detail 47638 C57BL/6J ±  kb
    transcript NM_016896 RefSeq | MGI Sequence Detail 4173 ZRU/MplStud  
    polypeptide Q9WUL6 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18699, MGI:101874
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 11
      Phenotypes 179
    • Earliest
      J:16865 Miyawaki S, et al., A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994 Feb;24(2):429-34
    • Latest
      J:357636 Cao M, et al., Inhibiting NF-kappaB inducing kinase improved the motor performance of ALS animal model. Brain Res. 2024 Nov 15;1843:149124
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory