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Nptx2 Gene Detail
Summary
  • Symbol
    Nptx2
  • Name
    neuronal pentraxin 2
  • Synonyms
    narp, np2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858209
    NCBI Gene: 53324
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144482712-144494288 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 84.58 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    422 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858209
 protein coding gene Chr5:144482697-144494288 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030350
 protein coding gene Chr5:149911219-149926488 (+)
A/J MGP_AJ_G0030319
 protein coding gene Chr5:143466209-143480548 (+)
AKR/J MGP_AKRJ_G0030251
 protein coding gene Chr5:147941316-147953026 (+)
BALB/cJ MGP_BALBcJ_G0030336
 protein coding gene Chr5:144737140-144752186 (+)
C3H/HeJ MGP_C3HHeJ_G0030047
 protein coding gene Chr5:148778588-148790426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030781
 protein coding gene Chr5:155392426-155406101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028000
 protein coding gene Chr5:137243364-137254866 (+)
CAST/EiJ MGP_CASTEiJ_G0029452
 protein coding gene Chr5:148333380-148344890 (+)
CBA/J MGP_CBAJ_G0030017
 protein coding gene Chr5:161780462-161798126 (+)
DBA/2J MGP_DBA2J_G0030167
 protein coding gene Chr5:143216848-143228283 (+)
FVB/NJ MGP_FVBNJ_G0030122
 protein coding gene Chr5:142435816-142447436 (+)
LP/J MGP_LPJ_G0030253
 protein coding gene Chr5:150500060-150511658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030153
 protein coding gene Chr5:164136345-164147790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030821
 protein coding gene Chr5:147842401-147854958 (+)
PWK/PhJ MGP_PWKPhJ_G0029167
 protein coding gene Chr5:142342408-142354204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029003
 protein coding gene Chr5:145571930-145583421 (+)
WSB/EiJ MGP_WSBEiJ_G0029525
 protein coding gene Chr5:148647543-148659819 (+)



Homology
more
  • Human Ortholog
    NPTX2, neuronal pentraxin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPTX2, neuronal pentraxin 2
  • Synonyms
    NARP, NP2, NP-II
  • Links
    NCBI Gene ID: 4885
    neXtProt AC: NX_P47972
    UniProt: P47972

  • Chr Location
    7q22.1; chr7:98617285-98629869 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059991 Ensembl Gene Model | MGI Sequence Detail 11577 C57BL/6J ±  kb
transcript ENSMUST00000071782 Ensembl | MGI Sequence Detail 2536 Not Applicable  
polypeptide ENSMUSP00000071687 Ensembl | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011383 neuronal pentraxin-2
    (term hierarchy)
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR051360 Neuronal Pentraxin and Related
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentraxin-related
  • GlyGen
    O70340 4 sites, 4 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16454, MGI:99669
References
more
  • Summaries
    All 53
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:32198 Tsui CC, et al., Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. J Neurosci. 1996 Apr 15;16(8):2463-78
  • Latest
    J:346430 Kanehisa K, et al., Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Nat Commun. 2022 May 2;13(1):2367
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory