Zranb2 MGI Mouse Gene Detail - MGI:1858211 - zinc finger, RAN-binding domain containing 2

Symbol

Zranb2
Name

zinc finger, RAN-binding domain containing 2
Synonyms

Zfp265, Zis, Znf265

Feature Type

protein coding gene
IDs

MGI:1858211
NCBI Gene: 53861
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:157239797-157254047 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 81.29 cM
Mapping Data

2 experiments

SNPs within 2kb

287 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858211	protein coding gene	Chr3:157239749-157254047 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028011	protein coding gene	Chr3:161672371-161686626 (+)
A/J	MGP_AJ_G0027969	protein coding gene	Chr3:155783002-155797190 (+)
AKR/J	MGP_AKRJ_G0027935	protein coding gene	Chr3:159916835-159931023 (+)
BALB/cJ	MGP_BALBcJ_G0027981	protein coding gene	Chr3:155589461-155603651 (+)
C3H/HeJ	MGP_C3HHeJ_G0027711	protein coding gene	Chr3:160318513-160332701 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028424	protein coding gene	Chr3:166954819-166969183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025763	protein coding gene	Chr3:150406877-150420980 (+)
CAST/EiJ	MGP_CASTEiJ_G0027164	protein coding gene	Chr3:160449192-160464518 (+)
CBA/J	MGP_CBAJ_G0027686	protein coding gene	Chr3:172885871-172900061 (+)
DBA/2J	MGP_DBA2J_G0027826	protein coding gene	Chr3:154827254-154841444 (+)
FVB/NJ	MGP_FVBNJ_G0027793	protein coding gene	Chr3:152177432-152191618 (+)
LP/J	MGP_LPJ_G0027937	protein coding gene	Chr3:163006310-163020546 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027826	protein coding gene	Chr3:181506176-181520362 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028483	protein coding gene	Chr3:159607824-159622012 (+)
PWK/PhJ	MGP_PWKPhJ_G0026887	protein coding gene	Chr3:154762743-154777018 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026715	protein coding gene	Chr3:157822573-157837691 (+)
WSB/EiJ	MGP_WSBEiJ_G0027244	protein coding gene	Chr3:160569317-160583553 (+)

Human Ortholog

ZRANB2, zinc finger RANBP2-type containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZRANB2, zinc finger RANBP2-type containing 2
Synonyms

ZIS, ZIS1, ZIS2, ZNF265
Links

HGNC:13058

NCBI Gene ID: 9406

neXtProt AC: NX_O95218

UniProt: O95218
Chr Location

1p31.1; chr1:71063291-71081289 (-) GRCh38

MGI Vertebrate Homology

Zranb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZRANB2
Protein SuperFamily

UCP037956_ZnF_Ran
Gene Tree

Zranb2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Gene trapped

14
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

31
cDNA Data

25
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zranb2

ZFIN zranb2

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All Sequences

99
RefSeq

28
UniProt

8
CCDS

CCDS51100.1, CCDS89715.1

Ensembl

ENSMUSG00000028180 (Evidence)
NCBI Gene

53861

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028180	Ensembl Gene Model \| MGI Sequence Detail	14251	C57BL/6J	± kb
transcript	ENSMUST00000106058	Ensembl \| MGI Sequence Detail	2924	Not Applicable
polypeptide	ENSMUSP00000101673	Ensembl \| MGI Sequence Detail	330	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000018217 zinc finger Ran-binding domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR017337 Zinc finger Ran-binding domain-containing protein 2

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily

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All nucleic 26

cDNA 25

Other 1

Microarray probesets 5

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MGI:2139650

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:61526 Adams DJ, et al., Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. Cytogenet Cell Genet. 2000;88(1-2):68-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zranb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32489	Chr3:157239740-157239797 (+)	-28 bp
Tssr32490	Chr3:157239988-157240048 (+)	221 bp
Tssr32491	Chr3:157242183-157242194 (+)	2,392 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24