Ube2k MGI Mouse Gene Detail - MGI:1858216 - ubiquitin-conjugating enzyme E2K

Symbol

Ube2k
Name

ubiquitin-conjugating enzyme E2K
Synonyms

D5Ertd601e, Hip2

Feature Type

protein coding gene
IDs

MGI:1858216
NCBI Gene: 53323
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:65694588-65756332 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.72 cM
Mapping Data

4 experiments

SNPs within 2kb

1081 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858216	protein coding gene	Chr5:65694576-65756332 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029581	protein coding gene	Chr5:65183125-65255227 (+)
A/J	MGP_AJ_G0029549	protein coding gene	Chr5:62763970-62822243 (+)
AKR/J	MGP_AKRJ_G0029497	protein coding gene	Chr5:64760124-64819529 (+)
BALB/cJ	MGP_BALBcJ_G0029558	protein coding gene	Chr5:63449761-63510435 (+)
C3H/HeJ	MGP_C3HHeJ_G0029281	protein coding gene	Chr5:65093616-65161166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030012	protein coding gene	Chr5:67861178-67943141 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027252	protein coding gene	Chr5:58840634-58897351 (+)
CAST/EiJ	MGP_CASTEiJ_G0028689	protein coding gene	Chr5:64199447-64260809 (+)
CBA/J	MGP_CBAJ_G0029250	protein coding gene	Chr5:70070194-70152000 (+)
DBA/2J	MGP_DBA2J_G0029396	protein coding gene	Chr5:62797354-62858965 (+)
FVB/NJ	MGP_FVBNJ_G0029356	protein coding gene	Chr5:61969530-62029498 (+)
LP/J	MGP_LPJ_G0029481	protein coding gene	Chr5:65693258-65758352 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029384	protein coding gene	Chr5:72948430-73024029 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030045	protein coding gene	Chr5:64424850-64491821 (+)
PWK/PhJ	MGP_PWKPhJ_G0028413	protein coding gene	Chr5:61770087-61838247 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028247	protein coding gene	Chr5:63754572-63832250 (+)
WSB/EiJ	MGP_WSBEiJ_G0028769	protein coding gene	Chr5:64625459-64699589 (+)

Human Ortholog

UBE2K, ubiquitin conjugating enzyme E2 K

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2K, ubiquitin conjugating enzyme E2 K
Synonyms

E2-25K, HIP2, HYPG, LIG, UBC1
Links

HGNC:4914

NCBI Gene ID: 3093

neXtProt AC: NX_P61086

UniProt: P61086
Chr Location

4p14; chr4:39698109-39782792 (+) GRCh38

MGI Vertebrate Homology

Ube2k stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UBE2K
Gene Tree

Ube2k

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

179
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

167
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Ube2k
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

69 strains or lines available

Mice homozygous for a hypomorphic allele exhibit resistance to amyloid-beta neurotoxicity.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

101
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2k

ZFIN ube2ka, ube2kb

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All Sequences

81
RefSeq

7
UniProt

9
CCDS

CCDS39098.1, CCDS80289.1

Ensembl

ENSMUSG00000029203 (Evidence)
NCBI Gene

53323

			Length	Strain/Species	Flank
genomic	53323	NCBI Gene Model \| MGI Sequence Detail	61745	C57BL/6J	± kb
transcript	NM_016786	RefSeq \| MGI Sequence Detail	4882	ZRU/MplStud
polypeptide	P61087	UniProt \| EBI \| MGI Sequence Detail	200	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016980 ubiquitin-conjugating enzyme E2 K

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

IPR042599 Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain
GlyGen

P61087 1 site, 1 O-linked glycan (1 site)

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All nucleic 26

cDNA 23

Primer pair 2

Other 1

Microarray probesets 10

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MGI:1277174, MGI:2141198

Summaries

All 65

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 29
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ube2k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46466	Chr5:65694184-65694189 (+)	-401 bp
Tssr46467	Chr5:65694195-65694215 (+)	-383 bp
Tssr46468	Chr5:65694224-65694243 (+)	-354 bp
Tssr46469	Chr5:65694247-65694274 (+)	-327 bp
Tssr46470	Chr5:65694552-65694557 (+)	-33 bp
Tssr46471	Chr5:65694598-65694609 (+)	16 bp
Tssr46472	Chr5:65694610-65694674 (+)	54 bp
Tssr46473	Chr5:65694687-65694700 (+)	106 bp
Tssr46474	Chr5:65696862-65696879 (+)	2,283 bp
Tssr46477	Chr5:65736347-65736364 (+)	41,768 bp
Tssr46478	Chr5:65742122-65742134 (+)	47,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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