Tuba8 MGI Mouse Gene Detail - MGI:1858225

Symbol

Tuba8
Name

tubulin, alpha 8

Feature Type

protein coding gene
IDs

MGI:1858225
NCBI Gene: 53857
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:121187655-121203813 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.15 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858225	protein coding gene	Chr6:121187655-121209304 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031214	protein coding gene	Chr6:124147833-124165323 (+)
A/J	MGP_AJ_G0031183	protein coding gene	Chr6:119364602-119381116 (+)
AKR/J	MGP_AKRJ_G0031114	protein coding gene	Chr6:122588785-122604705 (+)
BALB/cJ	MGP_BALBcJ_G0031194	protein coding gene	Chr6:119132510-119148675 (+)
C3H/HeJ	MGP_C3HHeJ_G0030912	protein coding gene	Chr6:122615904-122632703 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031652	protein coding gene	Chr6:127325851-127341713 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028812	protein coding gene	Chr6:116264695-116282493 (+)
CAST/EiJ	MGP_CASTEiJ_G0030301	protein coding gene	Chr6:123057173-123078142 (+)
CBA/J	MGP_CBAJ_G0030877	protein coding gene	Chr6:132386485-132402467 (+)
DBA/2J	MGP_DBA2J_G0031033	protein coding gene	Chr6:118256803-118272703 (+)
FVB/NJ	MGP_FVBNJ_G0030985	protein coding gene	Chr6:117400822-117417707 (+)
LP/J	MGP_LPJ_G0031112	protein coding gene	Chr6:124138360-124154254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031019	protein coding gene	Chr6:136323848-136341942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031681	protein coding gene	Chr6:122620924-122638407 (+)
PWK/PhJ	MGP_PWKPhJ_G0030016	protein coding gene	Chr6:117298200-117314655 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029845	protein coding gene	Chr6:121362525-121377859 (+)
WSB/EiJ	MGP_WSBEiJ_G0030384	protein coding gene	Chr6:122912960-122930830 (+)

Human Ortholog

TUBA8, tubulin alpha 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUBA8, tubulin alpha 8
Synonyms

CDCBM8, MACTHC2, TUBAL2
Links

HGNC:12410

NCBI Gene ID: 51807

neXtProt AC: NX_Q9NY65

UniProt: Q9NY65
Chr Location

22q11.21; chr22:18110100-18146683 (+) GRCh38

MGI Vertebrate Homology

Tuba8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TUBA8
Gene Tree

Tuba8

Diseases

1 with human TUBA8 associations

				Human Disease	Mouse Models
				thrombocytopenia IDs thrombocytopenia DOID:1588 ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 UMLS_CUI:C0040034

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Gene trapped

9
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele appear neurologically normal, progress to adulthood and exhibit normal fertility.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

83
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tuba8

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS39615.1

Ensembl

ENSMUSG00000030137 (Evidence)
NCBI Gene

53857

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030137	Ensembl Gene Model \| MGI Sequence Detail	16159	C57BL/6J	± kb
transcript	ENSMUST00000032233	Ensembl \| MGI Sequence Detail	2263	Not Applicable
polypeptide	ENSMUSP00000032233	Ensembl \| MGI Sequence Detail	449	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016813 tubulin alpha-8 chain

(term hierarchy)
EC

3.6.5.-
InterPro Domains

IPR002452 Alpha tubulin

IPR000217 Tubulin

IPR017975 Tubulin, conserved site

IPR023123 Tubulin, C-terminal

IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

IPR008280 Tubulin/FtsZ, C-terminal

IPR003008 Tubulin/FtsZ, GTPase domain

IPR036525 Tubulin/FtsZ, GTPase domain superfamily

IPR037103 Tubulin/FtsZ-like, C-terminal domain
GlyGen

Q9JJZ2 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 6

Diseases 1

Gene Ontology 5

Phenotypes 7
Earliest

J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tuba8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58565	Chr6:121187637-121187646 (+)	-13 bp
Tssr58566	Chr6:121187671-121187678 (+)	20 bp
Tssr58567	Chr6:121187690-121187717 (+)	49 bp
Tssr58568	Chr6:121187730-121187745 (+)	83 bp
Tssr58569	Chr6:121187750-121187772 (+)	106 bp
Tssr58570	Chr6:121203286-121203293 (+)	15,635 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24