Caprin1 MGI Mouse Gene Detail - MGI:1858234 - cell cycle associated protein 1

Symbol

Caprin1
Name

cell cycle associated protein 1
Synonyms

caprin-1, Gpiap1, MMGPIP137, RNG105

Feature Type

protein coding gene
IDs

MGI:1858234
NCBI Gene: 53872
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:103593292-103627946 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.43 cM
Mapping Data

2 experiments

SNPs within 2kb

548 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858234	protein coding gene	Chr2:103593286-103627994 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026207	protein coding gene	Chr2:105752128-105793510 (-)
A/J	MGP_AJ_G0026168	protein coding gene	Chr2:101393520-101428058 (-)
AKR/J	MGP_AKRJ_G0026149	protein coding gene	Chr2:104145313-104180580 (-)
BALB/cJ	MGP_BALBcJ_G0026177	protein coding gene	Chr2:101687474-101723027 (-)
C3H/HeJ	MGP_C3HHeJ_G0025928	protein coding gene	Chr2:104485794-104523191 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026628	protein coding gene	Chr2:109293375-109336246 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024019	protein coding gene	Chr2:97072795-97106301 (-)
CAST/EiJ	MGP_CASTEiJ_G0025393	protein coding gene	Chr2:104958846-104996274 (-)
CBA/J	MGP_CBAJ_G0025906	protein coding gene	Chr2:113020134-113054346 (-)
DBA/2J	MGP_DBA2J_G0026043	protein coding gene	Chr2:100956080-100991126 (-)
FVB/NJ	MGP_FVBNJ_G0026005	protein coding gene	Chr2:99954573-99990389 (-)
LP/J	MGP_LPJ_G0026146	protein coding gene	Chr2:105889244-105925652 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026031	protein coding gene	Chr2:116954738-117003273 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026682	protein coding gene	Chr2:104358373-104394736 (-)
PWK/PhJ	MGP_PWKPhJ_G0025128	protein coding gene	Chr2:100469257-100504128 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024929	protein coding gene	Chr2:103574101-103608880 (-)
WSB/EiJ	MGP_WSBEiJ_G0025460	protein coding gene	Chr2:105064854-105102608 (-)

Human Ortholog

CAPRIN1, cell cycle associated protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPRIN1, cell cycle associated protein 1
Synonyms

CONDCAC, GPIAP1, GPIP137, GRIP137, M11S1, NEDLAAD, p137GPI, RNG105
Links

HGNC:6743

NCBI Gene ID: 4076

neXtProt AC: NX_Q14444

UniProt: Q14444
Chr Location

11p13; chr11:34051731-34102610 (+) GRCh38

MGI Vertebrate Homology

Caprin1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CAPRIN1
Gene Tree

Caprin1

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

64
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Caprin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased fetal size, bent posture, cyanosis, respiratory failure, and neonatal lethality with impaired neuronal network development and reduced dendritic localization of sodium potassium ATPase subunit isoform mRNAs.

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All GO Annotations

47
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

52
cDNA Data

23
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAPRIN1

Xenbase caprin1

ZFIN caprin1a

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All Sequences

125
RefSeq

30
UniProt

9
CCDS

CCDS16481.1

Ensembl

ENSMUSG00000027184 (Evidence)
NCBI Gene

53872

			Length	Strain/Species	Flank
genomic	53872	NCBI Gene Model \| MGI Sequence Detail	34655	C57BL/6J	± kb
transcript	NM_001412577	RefSeq \| MGI Sequence Detail	6181	C57BL/6
polypeptide	Q60865	UniProt \| EBI \| MGI Sequence Detail	707	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000005024 caprin-1

(term hierarchy)
InterPro Domains

IPR028816 Caprin

IPR041637 Caprin-1 dimerization domain

IPR022070 Cytoplasmic activation/proliferation-associated protein-1 C term
GlyGen

Q60865 3 sites, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 9

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MGI:2139127

Summaries

All 60

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:321695 Nolan LS, et al., Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice. Sci Rep. 2022 Feb 14;12(1):2444

TSS for Caprin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25503	Chr2:103627962-103628007 (-)	-39 bp
Tssr25502	Chr2:103627937-103627957 (-)	-1 bp
Tssr586	Chr2:103627914-103627919 (-)	29 bp
Tssr25501	Chr2:103627334-103627433 (-)	562 bp
Tssr25500	Chr2:103627281-103627323 (-)	644 bp
Tssr25499	Chr2:103613504-103613517 (-)	14,435 bp
Tssr25498	Chr2:103609711-103609746 (-)	18,217 bp
Tssr25497	Chr2:103606299-103606317 (-)	21,638 bp
Tssr25496	Chr2:103603390-103603406 (-)	24,548 bp
Tssr25495	Chr2:103599223-103599251 (-)	28,709 bp
Tssr25494	Chr2:103596840-103596854 (-)	31,099 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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