Mpp2 MGI Mouse Gene Detail - MGI:1858257 - membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

Symbol

Mpp2
Name

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms

D11Bwg0652e, Dlg2, Dlgh2, Pals4

Feature Type

protein coding gene
IDs

MGI:1858257
NCBI Gene: 50997
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:101947841-101979341 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM
Mapping Data

2 experiments

SNPs within 2kb

1012 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858257	protein coding gene	Chr11:101947841-101979464 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019219	protein coding gene	Chr11:105000574-105032207 (-)
A/J	MGP_AJ_G0019187	protein coding gene	Chr11:100567753-100600004 (-)
AKR/J	MGP_AKRJ_G0019156	protein coding gene	Chr11:103683288-103714731 (-)
BALB/cJ	MGP_BALBcJ_G0019161	protein coding gene	Chr11:101053177-101084587 (-)
C3H/HeJ	MGP_C3HHeJ_G0018970	protein coding gene	Chr11:103886397-103919328 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019610	protein coding gene	Chr11:108274583-108307677 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017236	protein coding gene	Chr11:97992886-98025353 (-)
CAST/EiJ	MGP_CASTEiJ_G0018524	protein coding gene	Chr11:104854819-104889215 (-)
CBA/J	MGP_CBAJ_G0018939	protein coding gene	Chr11:112744837-112781292 (-)
DBA/2J	MGP_DBA2J_G0019051	protein coding gene	Chr11:100094216-100125645 (-)
FVB/NJ	MGP_FVBNJ_G0019041	protein coding gene	Chr11:99622072-99653386 (-)
LP/J	MGP_LPJ_G0019120	protein coding gene	Chr11:105518513-105551061 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019072	protein coding gene	Chr11:112271374-112302827 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019648	protein coding gene	Chr11:104046197-104077736 (-)
PWK/PhJ	MGP_PWKPhJ_G0018287	protein coding gene	Chr11:101156104-101188164 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018079	protein coding gene	Chr11:103800323-103832930 (-)
WSB/EiJ	MGP_WSBEiJ_G0018573	protein coding gene	Chr11:104027635-104068400 (-)

Human Ortholog

MPP2, MAGUK p55 scaffold protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPP2, MAGUK p55 scaffold protein 2
Synonyms

DLG2
Links

HGNC:7220

NCBI Gene ID: 4355

neXtProt AC: NX_Q14168

UniProt: Q14168
Chr Location

17q21.31; chr17:43875357-43909711 (-) GRCh38

MGI Vertebrate Homology

Mpp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MPP2
Gene Tree

Mpp2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Mpp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

32
cDNA Data

34
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpp2

ZFIN mpp2b

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All Sequences

65
RefSeq

26
UniProt

1
CCDS

CCDS25485.1, CCDS88261.1

Ensembl

ENSMUSG00000017314 (Evidence)
NCBI Gene

50997

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017314	Ensembl Gene Model \| MGI Sequence Detail	31501	C57BL/6J	± kb
transcript	ENSMUST00000100398	Ensembl \| MGI Sequence Detail	3577	Not Applicable
polypeptide	ENSMUSP00000097967	Ensembl \| MGI Sequence Detail	569	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029124 MAGUK p55 subfamily member 2

(term hierarchy)
InterPro Domains

IPR020590 Guanylate kinase, conserved site

IPR008144 Guanylate kinase-like domain

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR004172 L27 domain

IPR014775 L27 domain, C-terminal

IPR036892 L27 domain superfamily

IPR050716 Membrane-associated guanylate kinase

IPR035602 MPP2, SH3 domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q9WV34 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 36

cDNA 35

Primer pair 1

Microarray probesets 2

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MGD-MRK-34058, MGI:106365

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 12
Earliest

J:37257 Elder B, et al., cDNA sequence and genomic structure of the murine p55 (Mpp1) gene. Genomics. 1996 Dec 1;38(2):231-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mpp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110991	Chr11:101979366-101979380 (-)	-32 bp
Tssr110990	Chr11:101979297-101979356 (-)	14 bp
Tssr110989	Chr11:101979265-101979296 (-)	60 bp
Tssr110988	Chr11:101973290-101973319 (-)	6,036 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24