About   Help   FAQ
Semg1 Gene Detail
Summary
  • Symbol
    Semg1
  • Name
    semenogelin 1
  • Synonyms
    semenoclotin, Svs2, SVS II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858275
    NCBI Gene: 53878
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164077849-164080261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858275
 protein coding gene Chr2:164077849-164080386 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026842
 protein coding gene Chr2:169624512-169627058 (-)
A/J MGP_AJ_G0026808
 protein coding gene Chr2:162758792-162761329 (-)
AKR/J MGP_AKRJ_G0026779
 protein coding gene Chr2:167581046-167583583 (-)
BALB/cJ MGP_BALBcJ_G0026817
 protein coding gene Chr2:163099988-163102525 (-)
C3H/HeJ MGP_C3HHeJ_G0026559
 protein coding gene Chr2:167935105-167937642 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027265
 protein coding gene Chr2:174561462-174563999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024636
 protein coding gene Chr2:156173929-156177175 (-)
CAST/EiJ MGP_CASTEiJ_G0026020
 protein coding gene Chr2:168362254-168364797 (-)
CBA/J MGP_CBAJ_G0026536
 protein coding gene Chr2:180856620-180859157 (-)
DBA/2J MGP_DBA2J_G0026674
 protein coding gene Chr2:161928060-161930597 (-)
FVB/NJ MGP_FVBNJ_G0026640
 protein coding gene Chr2:160304233-160306770 (-)
LP/J MGP_LPJ_G0026777
 protein coding gene Chr2:169729818-169732364 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026662
 protein coding gene Chr2:184509184-184511737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027321
 protein coding gene Chr2:167487673-167490210 (-)
PWK/PhJ MGP_PWKPhJ_G0025754
 protein coding gene Chr2:161508266-161510811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025557
 protein coding gene Chr2:166353929-166356908 (-)
WSB/EiJ MGP_WSBEiJ_G0026090
 protein coding gene Chr2:168347976-168350513 (-)



Homology
more
  • Human Ortholog
    SEMG1, semenogelin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMG1, semenogelin 1
  • Synonyms
    CT103, dJ172H20.2, SEMG, SGI
  • Links
    NCBI Gene ID: 6406
    neXtProt AC: NX_P04279
    UniProt: P04279

  • Chr Location
    20q13.12; chr20:45207033-45209768 (+)  GRCh38
  • Human Ortholog
    SEMG2, semenogelin 2
  • Synonyms
    SGII
  • Links
    NCBI Gene ID: 6407
    neXtProt AC: NX_Q02383
    UniProt: Q02383

  • Chr Location
    20q13.12; chr20:45221373-45224458 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele display severely reduced fertility with premature acrosome reaction, absence of copulatory plug formation and intrauterine death of sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    8
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53878 NCBI Gene Model | MGI Sequence Detail 2413 C57BL/6J ±  kb
    transcript NM_017390 RefSeq | MGI Sequence Detail 1570 ZRU/MplStud  
    polypeptide NP_059086 RefSeq | MGI Sequence Detail 375 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR008836 Semenogelin
      IPR002080 Seminal vesicle protein II, conserved site
      IPR018942 Seminal vesicle protein repeat
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139431, MGI:6718886
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:31528 Lundwall A, The cloning of a rapidly evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semen. Eur J Biochem. 1996 Jan 15;235(1-2):424-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory