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Ddx20 Gene Detail
Summary
  • Symbol
    Ddx20
  • Name
    DEAD box helicase 20
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20, dp103, GEMIN3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858415
    NCBI Gene: 53975
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105585586-105594890 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.43 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858415
 protein coding gene Chr3:105585586-105595104 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027718
 protein coding gene Chr3:107053163-107062379 (-)
A/J MGP_AJ_G0027678
 protein coding gene Chr3:103626136-103635403 (-)
AKR/J MGP_AKRJ_G0027643
 protein coding gene Chr3:106199196-106210202 (-)
BALB/cJ MGP_BALBcJ_G0027690
 protein coding gene Chr3:103410835-103419930 (-)
C3H/HeJ MGP_C3HHeJ_G0027420
 protein coding gene Chr3:106539155-106548410 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028134
 protein coding gene Chr3:111053397-111063856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025474
 protein coding gene Chr3:99705883-99714790 (-)
CAST/EiJ MGP_CASTEiJ_G0026876
 protein coding gene Chr3:105690121-105699167 (-)
CBA/J MGP_CBAJ_G0027395
 protein coding gene Chr3:114795409-114804654 (-)
DBA/2J MGP_DBA2J_G0027537
 protein coding gene Chr3:102865879-102875350 (-)
FVB/NJ MGP_FVBNJ_G0027505
 protein coding gene Chr3:100798995-100808395 (-)
LP/J MGP_LPJ_G0027644
 protein coding gene Chr3:108454629-108463826 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027535
 protein coding gene Chr3:120910346-120919441 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028189
 protein coding gene Chr3:105748543-105757650 (-)
PWK/PhJ MGP_PWKPhJ_G0026602
 protein coding gene Chr3:102647544-102656963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026423
 protein coding gene Chr3:103780559-103789620 (-)
WSB/EiJ MGP_WSBEiJ_G0026956
 protein coding gene Chr3:106309867-106318943 (-)



Homology
more
  • Human Ortholog
    DDX20, DEAD-box helicase 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX20, DEAD-box helicase 20
  • Synonyms
    DP103, GEMIN3
  • Links
    NCBI Gene ID: 11218
    neXtProt AC: NX_Q9UHI6
    UniProt: Q9UHI6

  • Chr Location
    1p13.2; chr1:111754832-111775602 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele fail to implant and develop past the 2-cell stage. Heterozygous null females are viable, healthy and fertile but show increased ovary weight, a greater number of empty follicles, a prolonged estrous phase, and reduced nocturnal and stress-induced serum ACTH levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    26
  • cDNA Data
    83
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027905 Ensembl Gene Model | MGI Sequence Detail 9305 C57BL/6J ±  kb
    transcript ENSMUST00000090680 Ensembl | MGI Sequence Detail 2905 Not Applicable  
    polypeptide ENSMUSP00000088176 Ensembl | MGI Sequence Detail 825 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 84
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 14
      Phenotypes 14
    • Earliest
      J:61764 Campbell L, et al., Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation?. Hum Mol Genet. 2000 Apr 12;9(7):1093-100
    • Latest
      J:348424 Zou D, et al., DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice. Dev Cell. 2024 Apr 22;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory