Ramp1 MGI Mouse Gene Detail - MGI:1858418 - receptor (calcitonin) activity modifying protein 1

Symbol

Ramp1
Name

receptor (calcitonin) activity modifying protein 1
Synonyms

9130218E19Rik

Feature Type

protein coding gene
IDs

MGI:1858418
NCBI Gene: 51801
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:91107544-91152918 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.08 cM
Mapping Data

4 experiments

SNPs within 2kb

1281 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858418	protein coding gene	Chr1:91107544-91152918 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016302	protein coding gene	Chr1:92707553-92758781 (+)
A/J	MGP_AJ_G0016283	protein coding gene	Chr1:89371342-89417469 (+)
AKR/J	MGP_AKRJ_G0016244	protein coding gene	Chr1:92032615-92079533 (+)
BALB/cJ	MGP_BALBcJ_G0016239	protein coding gene	Chr1:89558462-89604003 (+)
C3H/HeJ	MGP_C3HHeJ_G0016068	protein coding gene	Chr1:92240588-92286371 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016698	protein coding gene	Chr1:96276687-96321704 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014416	protein coding gene	Chr1:83635206-83680566 (+)
CAST/EiJ	MGP_CASTEiJ_G0015653	protein coding gene	Chr1:91578234-91630160 (+)
CBA/J	MGP_CBAJ_G0016044	protein coding gene	Chr1:99350664-99398256 (+)
DBA/2J	MGP_DBA2J_G0016147	protein coding gene	Chr1:88600558-88645531 (+)
FVB/NJ	MGP_FVBNJ_G0016146	protein coding gene	Chr1:87630411-87676421 (+)
LP/J	MGP_LPJ_G0016218	protein coding gene	Chr1:93873803-93918749 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016171	protein coding gene	Chr1:102604183-102649460 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016738	protein coding gene	Chr1:92054357-92101867 (+)
PWK/PhJ	MGP_PWKPhJ_G0015437	protein coding gene	Chr1:88013966-88059684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015220	protein coding gene	Chr1:90979884-91029219 (+)
WSB/EiJ	MGP_WSBEiJ_G0015711	protein coding gene	Chr1:91841849-91888184 (+)

Human Ortholog

RAMP1, receptor activity modifying protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAMP1, receptor activity modifying protein 1
Links

HGNC:9843

NCBI Gene ID: 10267

neXtProt AC: NX_O60894

UniProt: O60894
Chr Location

2q37.3; chr2:237858880-237912106 (+) GRCh38

MGI Vertebrate Homology

Ramp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAMP1
Gene Tree

Ramp1

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
51 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Ramp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit high systolic blood pressure due to a disruption in vasodilatory regulation as well as significantly increased serum levels of proinflammatory cytokines following LPS administration.

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All GO Annotations

46
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

50
cDNA Data

33
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ramp1

ZFIN ramp1

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All Sequences

58
RefSeq

8
UniProt

6
CCDS

CCDS15158.1, CCDS48321.1, CCDS78648.1

Ensembl

ENSMUSG00000034353 (Evidence)
NCBI Gene

51801

			Length	Strain/Species	Flank
genomic	51801	NCBI Gene Model \| MGI Sequence Detail	45375	C57BL/6J	± kb
transcript	NM_016894	RefSeq \| MGI Sequence Detail	2549	ZRU/MplStud
polypeptide	Q9WTJ5	UniProt \| EBI \| MGI Sequence Detail	148	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013705 receptor activity-modifying protein 1

(term hierarchy)
InterPro Domains

IPR038126 RAMP domain superfamily

IPR006985 Receptor activity modifying protein

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All nucleic 33

cDNA 33

Microarray probesets 5

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MGI:1924927

Summaries

All 90

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 51
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:359108 Fattori V, et al., Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice. Sci Transl Med. 2024 Nov 6;16(772):eadk8230

TSS for Ramp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8059	Chr1:91107726-91107746 (+)	192 bp
Tssr8060	Chr1:91107747-91107777 (+)	218 bp
Tssr8061	Chr1:91107780-91107789 (+)	241 bp
Tssr8062	Chr1:91141953-91141980 (+)	34,423 bp
Tssr8063	Chr1:91142246-91142260 (+)	34,709 bp
Tssr8064	Chr1:91142277-91142301 (+)	34,745 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24