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Rnase2b Gene Detail
Summary
  • Symbol
    Rnase2b
  • Name
    ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
  • Synonyms
    Ear5, mR5, murine ribonuclease 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858598
    NCBI Gene: 54159
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51399717-51400475 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.40 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858598
 protein coding gene Chr14:51399717-51400475 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021276
 protein coding gene Chr14:45135563-45136321 (+)
A/J MGP_AJ_G0021231
 protein coding gene Chr14:43781710-43782468 (+)
AKR/J MGP_AKRJ_G0021207
 protein coding gene Chr14:45433708-45434466 (+)
BALB/cJ MGP_BALBcJ_G0021234
 protein coding gene Chr14:43909176-43909934 (+)
C3H/HeJ MGP_C3HHeJ_G0021016
 protein coding gene Chr14:45256046-45256804 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021670
 protein coding gene Chr14:46991279-46992037 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0020983
 protein coding gene Chr14:48432061-48432819 (+)
DBA/2J MGP_DBA2J_G0021107
 protein coding gene Chr14:43668553-43669311 (+)
FVB/NJ MGP_FVBNJ_G0021086
 protein coding gene Chr14:43301907-43302762 (+)
LP/J MGP_LPJ_G0021174
 protein coding gene Chr14:45431047-45431805 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021114
 protein coding gene Chr14:47951167-47952022 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021699
 protein coding gene Chr14:44911714-44912472 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Synonyms
    EDN, RAF3, RNS2
  • Links
    NCBI Gene ID: 6036
    neXtProt AC: NX_P10153
    UniProt: P10153

  • Chr Location
    14q11.2; chr14:20955487-20956436 (+)  GRCh38
  • Human Ortholog
    RNASE3, ribonuclease A family member 3
  • Synonyms
    ECP, RAF1, RNS3
  • Links
    NCBI Gene ID: 6037
    neXtProt AC: NX_P12724
    UniProt: P12724

  • Chr Location
    14q11.2; chr14:20891385-20892348 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Genomic Mutations
    1 involving Rnase2b
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54159 NCBI Gene Model | MGI Sequence Detail 759 C57BL/6J ±  kb
transcript NM_019398 RefSeq | MGI Sequence Detail 759 C57BL/6  
polypeptide O35292 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory