Blcap MGI Mouse Gene Detail - MGI:1858907 - bladder cancer associated protein

Symbol

Blcap
Name

bladder cancer associated protein
Synonyms

Bc10

Feature Type

protein coding gene
IDs

MGI:1858907
NCBI Gene: 53619
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:157398282-157408281 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.40 cM
Mapping Data

3 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858907	protein coding gene	Chr2:157398282-157413194 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026783	protein coding gene	Chr2:162572288-162589909 (-)
A/J	MGP_AJ_G0026749	protein coding gene	Chr2:156071475-156086169 (-)
AKR/J	MGP_AKRJ_G0026720	protein coding gene	Chr2:160670348-160689029 (-)
BALB/cJ	MGP_BALBcJ_G0026758	protein coding gene	Chr2:156356877-156375809 (-)
C3H/HeJ	MGP_C3HHeJ_G0026500	protein coding gene	Chr2:160974467-160989117 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027207	protein coding gene	Chr2:167406918-167421509 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024577	protein coding gene	Chr2:149523202-149538072 (-)
CAST/EiJ	MGP_CASTEiJ_G0025962	protein coding gene	Chr2:161327116-161343197 (-)
CBA/J	MGP_CBAJ_G0026477	protein coding gene	Chr2:173423813-173445021 (-)
DBA/2J	MGP_DBA2J_G0026615	protein coding gene	Chr2:155245366-155260624 (-)
FVB/NJ	MGP_FVBNJ_G0026582	protein coding gene	Chr2:153639782-153656170 (-)
LP/J	MGP_LPJ_G0026718	protein coding gene	Chr2:162660821-162677643 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026603	protein coding gene	Chr2:177266031-177284258 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027263	protein coding gene	Chr2:160486746-160502637 (-)
PWK/PhJ	MGP_PWKPhJ_G0025696	protein coding gene	Chr2:154768349-154784202 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025499	protein coding gene	Chr2:159427152-159442067 (-)
WSB/EiJ	MGP_WSBEiJ_G0026032	protein coding gene	Chr2:161376846-161394437 (-)

Human Ortholog

BLCAP, BLCAP apoptosis inducing factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BLCAP, BLCAP apoptosis inducing factor
Synonyms

BC10
Links

HGNC:1055

NCBI Gene ID: 10904

neXtProt AC: NX_P62952

UniProt: P62952
Chr Location

20q11.23; chr20:37492472-37527931 (-) GRCh38

MGI Vertebrate Homology

Blcap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BLCAP
Gene Tree

Blcap

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

2
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase blcap

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS16979.1

Ensembl

ENSMUSG00000067787 (Evidence)
NCBI Gene

53619

			Length	Strain/Species	Flank
genomic	53619	NCBI Gene Model \| MGI Sequence Detail	10000	C57BL/6J	± kb
transcript	NM_001355426	RefSeq \| MGI Sequence Detail	2108	C57BL/6
polypeptide	P62951	UniProt \| EBI \| MGI Sequence Detail	87	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004756 bladder cancer-associated protein

(term hierarchy)
InterPro Domains

IPR009598 Bladder cancer-related BC10

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGI:2138970

Summaries

All 35

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Blcap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27189	Chr2:157408620-157408643 (-)	-351 bp
Tssr27188	Chr2:157408239-157408270 (-)	26 bp
Tssr27187	Chr2:157408214-157408225 (-)	61 bp
Tssr27186	Chr2:157403899-157403934 (-)	4,364 bp
Tssr27185	Chr2:157403772-157403804 (-)	4,493 bp
Tssr27184	Chr2:157402889-157402893 (-)	5,390 bp
Tssr27183	Chr2:157402782-157402803 (-)	5,488 bp
Tssr27182	Chr2:157399526-157399529 (-)	8,753 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24