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Jmjd6 Gene Detail
Summary
  • Symbol
    Jmjd6
  • Name
    jumonji domain containing 6
  • Synonyms
    5730436I23Rik, mKIAA0585, PSR, PtdSerR, Ptdsr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858910
    NCBI Gene: 107817
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116728258-116734275 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.49 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858910
 protein coding gene Chr11:116728258-116734593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019440
 protein coding gene Chr11:121000270-121006296 (-)
A/J MGP_AJ_G0019408
 protein coding gene Chr11:115662623-115668649 (-)
AKR/J MGP_AKRJ_G0019378
 protein coding gene Chr11:119198173-119204199 (-)
BALB/cJ MGP_BALBcJ_G0019383
 protein coding gene Chr11:116055996-116062026 (-)
C3H/HeJ MGP_C3HHeJ_G0019189
 protein coding gene Chr11:119466462-119472488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019832
 protein coding gene Chr11:124727883-124733900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017455
 protein coding gene Chr11:112675335-112681385 (-)
CAST/EiJ MGP_CASTEiJ_G0018743
 protein coding gene Chr11:120886379-120892434 (-)
CBA/J MGP_CBAJ_G0019160
 protein coding gene Chr11:129587068-129593094 (-)
DBA/2J MGP_DBA2J_G0019272
 protein coding gene Chr11:115085057-115091083 (-)
FVB/NJ MGP_FVBNJ_G0019264
 protein coding gene Chr11:114644410-114650435 (-)
LP/J MGP_LPJ_G0019342
 protein coding gene Chr11:121346044-121352945 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019297
 protein coding gene Chr11:128642268-128648295 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019871
 protein coding gene Chr11:119829560-119835586 (-)
PWK/PhJ MGP_PWKPhJ_G0018508
 protein coding gene Chr11:116420404-116426506 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018301
 protein coding gene Chr11:119563203-119569244 (-)
WSB/EiJ MGP_WSBEiJ_G0018795
 protein coding gene Chr11:119773769-119779795 (-)



Homology
more
  • Human Ortholog
    JMJD6, jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JMJD6, jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  • Synonyms
    PSR, PTDSR, PTDSR1
  • Links
    NCBI Gene ID: 23210
    neXtProt AC: NX_Q6NYC1
    UniProt: Q6NYC1

  • Chr Location
    17q25.1; chr17:76712832-76726799 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show perinatal lethality. Abnormalities are observed in the nervous. respiratory, cardiovascular, digestive, renal, hematopoietic, and immune systems.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    74
  • cDNA Data
    87
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056962 Ensembl Gene Model | MGI Sequence Detail 6018 C57BL/6J ±  kb
    transcript ENSMUST00000047616 Ensembl | MGI Sequence Detail 1668 Not Applicable  
    polypeptide ENSMUSP00000047570 Ensembl | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 87
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261867, MGI:1917797
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 7
      Gene Ontology 16
      Phenotypes 24
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory