Ddah2 MGI Mouse Gene Detail - MGI:1859016 - DDAH family member 2, ADMA independent

Symbol

Ddah2
Name

DDAH family member 2, ADMA independent
Synonyms

Clone 7u, Ddah, G6a, NG30

Feature Type

protein coding gene
IDs

MGI:1859016
NCBI Gene: 51793
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:35278011-35281071 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.59 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859016	protein coding gene	Chr17:35278011-35281075 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023610	protein coding gene	Chr17:35198936-35201899 (+)
A/J	MGP_AJ_G0023570	protein coding gene	Chr17:34032894-34035870 (+)
AKR/J	MGP_AKRJ_G0023538	protein coding gene	Chr17:34507483-34510460 (+)
BALB/cJ	MGP_BALBcJ_G0023576	protein coding gene	Chr17:34169210-34172187 (+)
C3H/HeJ	MGP_C3HHeJ_G0023337	protein coding gene	Chr17:34900288-34903257 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024015	protein coding gene	Chr17:36535892-36538857 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021496	protein coding gene	Chr17:31800036-31802849 (+)
CAST/EiJ	MGP_CASTEiJ_G0022834	protein coding gene	Chr17:34902862-34905893 (+)
CBA/J	MGP_CBAJ_G0023315	protein coding gene	Chr17:38042924-38045892 (+)
DBA/2J	MGP_DBA2J_G0023443	protein coding gene	Chr17:33353191-33356163 (+)
FVB/NJ	MGP_FVBNJ_G0023410	protein coding gene	Chr17:33189709-33192680 (+)
LP/J	MGP_LPJ_G0023520	protein coding gene	Chr17:35524623-35527582 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023432	protein coding gene	Chr17:36978618-36981581 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024060	protein coding gene	Chr17:34726697-34729468 (+)
PWK/PhJ	MGP_PWKPhJ_G0022581	protein coding gene	Chr17:32186573-32189576 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022401	protein coding gene	Chr17:32736900-32739862 (+)
WSB/EiJ	MGP_WSBEiJ_G0022897	protein coding gene	Chr17:34845675-34848678 (+)

Human Ortholog

DDAH2, DDAH family member 2, ADMA-independent

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDAH2, DDAH family member 2, ADMA-independent
Synonyms

DDAH, DDAHII, G6a, HEL-S-277, NG30
Links

HGNC:2716

NCBI Gene ID: 23564

neXtProt AC: NX_O95865

UniProt: O95865
Chr Location

6p21.33; chr6:31727038-31730617 (-) GRCh38

MGI Vertebrate Homology

Ddah2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDAH2
Gene Tree

Ddah2

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice exhibit normal embryonic survival.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

106
cDNA Data

162
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddah2

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All Sequences

48
RefSeq

8
UniProt

4
CCDS

CCDS50082.1, CCDS57070.1

Ensembl

ENSMUSG00000007039 (Evidence)
NCBI Gene

51793

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007039	Ensembl Gene Model \| MGI Sequence Detail	3061	C57BL/6J	± kb
transcript	ENSMUST00000007255	Ensembl \| MGI Sequence Detail	1342	Not Applicable
polypeptide	ENSMUSP00000007255	Ensembl \| MGI Sequence Detail	285	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006339 putative hydrolase DDAH2

(term hierarchy)
EC

3.-.-.-
InterPro Domains

IPR033199 Dimethylarginine dimethylaminohydrolase-like
GlyGen

Q99LD8 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 163

Genomic 1

cDNA 162

Microarray probesets 3

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MGI:2146979, MGI:2147062

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 14
Earliest

J:44498 Spanjaard RA, et al., Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma. Cancer Res. 1997 Nov 15;57(22):5122-8
Latest

J:341706 Wu Y, et al., Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis. Sci Adv. 2023 Feb 10;9(6):eade5584

TSS for Ddah2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144193	Chr17:35277321-35277336 (+)	-682 bp
Tssr144194	Chr17:35278017-35278106 (+)	51 bp
Tssr144195	Chr17:35278121-35278132 (+)	116 bp
Tssr144196	Chr17:35278134-35278145 (+)	129 bp
Tssr144197	Chr17:35278149-35278164 (+)	146 bp
Tssr144198	Chr17:35278214-35278223 (+)	208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24