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Cacng3 Gene Detail
Summary
  • Symbol
    Cacng3
  • Name
    calcium channel, voltage-dependent, gamma subunit 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859165
    NCBI Gene: 54376
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122270967-122368616 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 66.81 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2552 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859165
 protein coding gene Chr7:122269715-122368616 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032957
 protein coding gene Chr7:126771659-126879373 (+)
A/J MGP_AJ_G0032940
 protein coding gene Chr7:123482643-123586155 (+)
AKR/J MGP_AKRJ_G0032872
 protein coding gene Chr7:126625879-126740743 (+)
BALB/cJ MGP_BALBcJ_G0032945
 protein coding gene Chr7:123169394-123271741 (+)
C3H/HeJ MGP_C3HHeJ_G0032655
 protein coding gene Chr7:126533226-126633784 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033451
 protein coding gene Chr7:131753208-131863324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030423
 protein coding gene Chr7:124793989-124893232 (+)
CAST/EiJ MGP_CASTEiJ_G0031983
 protein coding gene Chr7:118338819-118444691 (+)
CBA/J MGP_CBAJ_G0032628
 protein coding gene Chr7:136184325-136281665 (+)
DBA/2J MGP_DBA2J_G0032780
 protein coding gene Chr7:121475384-121576080 (+)
FVB/NJ MGP_FVBNJ_G0032733
 protein coding gene Chr7:121330820-121430074 (+)
LP/J MGP_LPJ_G0032874
 protein coding gene Chr7:128208572-128316341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032765
 protein coding gene Chr7:137539042-137641237 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033471
 protein coding gene Chr7:125623482-125731878 (+)
PWK/PhJ MGP_PWKPhJ_G0031691
 protein coding gene Chr7:114412647-114514146 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031537
 protein coding gene Chr7:112399960-112505736 (+)
WSB/EiJ MGP_WSBEiJ_G0032096
 protein coding gene Chr7:126538866-126651517 (+)



Homology
more
  • Human Ortholog
    CACNG3, calcium voltage-gated channel auxiliary subunit gamma 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNG3, calcium voltage-gated channel auxiliary subunit gamma 3
  • Links
    NCBI Gene ID: 10368
    neXtProt AC: NX_O60359
    UniProt: O60359

  • Chr Location
    16p12.1; chr16:24256335-24362412 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CACNG3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene have elevated cholesterol and HDL levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    78
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54376 NCBI Gene Model | MGI Sequence Detail 97650 C57BL/6J ±  kb
    transcript NM_019430 RefSeq | MGI Sequence Detail 1540 C57BL/6  
    polypeptide Q9JJV5 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004952 voltage-dependent calcium channel gamma-3 subunit
      (term hierarchy)
    • InterPro Domains
      IPR004031 PMP-22/EMP/MP20/Claudin
      IPR051072 Voltage-dependent calcium channel gamma subunit
      IPR008368 Voltage-dependent calcium channel, gamma subunit
    • GlyGen
      Q9JJV5 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 5
    • Earliest
      J:61749 Burgess DL, et al., Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec;9(12):1204-13
    • Latest
      J:231740 Yamasaki M, et al., TARP gamma-2 and gamma-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area. J Neurosci. 2016 Apr 13;36(15):4296-312
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory