Cacng6 MGI Mouse Gene Detail - MGI:1859168 - calcium channel, voltage-dependent, gamma subunit 6

Symbol

Cacng6
Name

calcium channel, voltage-dependent, gamma subunit 6
Synonyms

2310033H20Rik

Feature Type

protein coding gene
IDs

MGI:1859168
NCBI Gene: 54378
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:3472711-3484183 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.00 cM
Mapping Data

2 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859168	protein coding gene	Chr7:3472017-3484183 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031519	protein coding gene	Chr7:343696-355095 (+)
A/J	MGP_AJ_G0031494	protein coding gene	Chr7:333834-345237 (+)
AKR/J	MGP_AKRJ_G0031422	protein coding gene	Chr7:328391-339772 (+)
BALB/cJ	MGP_BALBcJ_G0031502	protein coding gene	Chr7:334680-346478 (+)
C3H/HeJ	MGP_C3HHeJ_G0031222	protein coding gene	Chr7:343017-354430 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031962	protein coding gene	Chr7:348649-359998 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029089	protein coding gene	Chr7:229535-241194 (+)
CAST/EiJ	MGP_CASTEiJ_G0030591	protein coding gene	Chr7:337634-350221 (+)
CBA/J	MGP_CBAJ_G0031182	protein coding gene	Chr7:450557-464812 (+)
DBA/2J	MGP_DBA2J_G0031339	protein coding gene	Chr7:325412-336891 (+)
FVB/NJ	MGP_FVBNJ_G0031291	protein coding gene	Chr7:322403-334453 (+)
LP/J	MGP_LPJ_G0031424	protein coding gene	Chr7:343089-363121 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031330	protein coding gene	Chr7:375578-387862 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031996	protein coding gene	Chr7:324145-336493 (+)
PWK/PhJ	MGP_PWKPhJ_G0030318	protein coding gene	Chr7:468587-480855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030142	protein coding gene	Chr7:399693-411117 (+)
WSB/EiJ	MGP_WSBEiJ_G0030685	protein coding gene	Chr7:333578-344869 (+)

Human Ortholog

CACNG6, calcium voltage-gated channel auxiliary subunit gamma 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CACNG6, calcium voltage-gated channel auxiliary subunit gamma 6
Links

HGNC:13625

NCBI Gene ID: 59285

neXtProt AC: NX_Q9BXT2

UniProt: Q9BXT2
Chr Location

19q13.42; chr19:53991149-54012666 (+) GRCh38

MGI Vertebrate Homology

Cacng6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CACNG6
Gene Tree

Cacng6

Diseases

1 with human CACNG6 associations

				Human Disease	Mouse Models
				aspirin-induced respiratory disease IDs aspirin-induced respiratory disease DOID:0080822

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

5
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

32
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cacng6

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All Sequences

40
RefSeq

6
UniProt

4
CCDS

CCDS39726.1

Ensembl

ENSMUSG00000078815 (Evidence)
NCBI Gene

54378

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078815	Ensembl Gene Model \| MGI Sequence Detail	11473	C57BL/6J	± kb
transcript	ENSMUST00000183200	Ensembl \| MGI Sequence Detail	1977	Not Applicable
polypeptide	ENSMUSP00000138622	Ensembl \| MGI Sequence Detail	260	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004955 voltage-dependent calcium channel gamma-6 subunit

(term hierarchy)
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin

IPR008370 Voltage-dependent calcium channel, gamma-6 subunit

IPR008368 Voltage-dependent calcium channel, gamma subunit

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 2

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MGI:1916809, MGI:2142197

Summaries

All 31

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 7
Earliest

J:61323 Klugbauer N, et al., A family of gamma-like calcium channel subunits. FEBS Lett. 2000 Mar 24;470(2):189-97
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cacng6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64271	Chr7:3472105-3472110 (+)	-603 bp
Tssr64272	Chr7:3472116-3472127 (+)	-589 bp
Tssr64273	Chr7:3472128-3472170 (+)	-562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24