Fmn2 MGI Mouse Gene Detail - MGI:1859252

Symbol

Fmn2
Name

formin 2

Feature Type

protein coding gene
IDs

MGI:1859252
NCBI Gene: 54418
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:174329391-174650295 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.04 cM
Mapping Data

3 experiments

SNPs within 2kb

10714 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859252	protein coding gene	Chr1:174324079-174650295 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016833	protein coding gene	Chr1:180560202-180903720 (+)
A/J	MGP_AJ_G0016812	protein coding gene	Chr1:173292511-173614947 (+)
AKR/J	MGP_AKRJ_G0016778	protein coding gene	Chr1:178469928-178806718 (+)
BALB/cJ	MGP_BALBcJ_G0016770	protein coding gene	Chr1:173803357-174139110 (+)
C3H/HeJ	MGP_C3HHeJ_G0016595	protein coding gene	Chr1:179074765-179414964 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017235	protein coding gene	Chr1:186603752-186955046 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014940	protein coding gene	Chr1:164655346-164967511 (+)
CAST/EiJ	MGP_CASTEiJ_G0016176	protein coding gene	Chr1:178444289-178771964 (+)
CBA/J	MGP_CBAJ_G0016569	protein coding gene	Chr1:193371612-193768605 (+)
DBA/2J	MGP_DBA2J_G0016674	protein coding gene	Chr1:172152983-172475220 (+)
FVB/NJ	MGP_FVBNJ_G0016671	protein coding gene	Chr1:170290259-170608585 (+)
LP/J	MGP_LPJ_G0016750	protein coding gene	Chr1:181717479-182081023 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016703	protein coding gene	Chr1:200588750-200956466 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017270	protein coding gene	Chr1:178262469-178599049 (+)
PWK/PhJ	MGP_PWKPhJ_G0015963	protein coding gene	Chr1:171231025-171562193 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015740	protein coding gene	Chr1:177275651-177605325 (+)
WSB/EiJ	MGP_WSBEiJ_G0016238	protein coding gene	Chr1:178437744-178772472 (+)

Human Ortholog

FMN2, formin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMN2, formin 2
Links

HGNC:14074

NCBI Gene ID: 56776

neXtProt AC: NX_Q9NZ56

UniProt: Q9NZ56
Chr Location

1q43; chr1:240014348-240475187 (+) GRCh38

MGI Vertebrate Homology

Fmn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMN2
Gene Tree

Fmn2

Diseases

1 with human FMN2 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 47 IDs autosomal recessive intellectual developmental disorder 47 DOID:0081211 OMIM:616193

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

4
Targeted

2
Genomic Mutations

2 involving Fmn2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a knock-out allele display polyploid embryo formation, recurrent pregnancy loss, hypofertility, and inadequate nursing behavior.

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All GO Annotations

50
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

74
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fmn2

ZFIN fmn2b

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All Sequences

50
RefSeq

6
UniProt

3
CCDS

CCDS48459.1

Ensembl

ENSMUSG00000028354 (Evidence)
NCBI Gene

54418

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028354	Ensembl Gene Model \| MGI Sequence Detail	320905	C57BL/6J	± kb
transcript	ENSMUST00000030039	Ensembl \| MGI Sequence Detail	6442	Not Applicable
polypeptide	ENSMUSP00000030039	Ensembl \| MGI Sequence Detail	1578	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007570 formin-2

(term hierarchy)
InterPro Domains

IPR015425 Formin, FH2 domain

IPR042201 Formin, FH2 domain superfamily

IPR001265 Formin homology family, Cappuccino subfamily
GlyGen

Q9JL04 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 23

Genomic 2

cDNA 15

Primer pair 6

Microarray probesets 8

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MGI:2138479

Summaries

All 65

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 25
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:347661 Nikalayevich E, et al., Aberrant cortex contractions impact mammalian oocyte quality. Dev Cell. 2024 Apr 8;59(7):841-852.e7

TSS for Fmn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10309	Chr1:174329362-174329409 (+)	-5 bp
Tssr10310	Chr1:174329416-174329453 (+)	44 bp
Tssr10311	Chr1:174579212-174579217 (+)	249,824 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24