Exoc7 MGI Mouse Gene Detail - MGI:1859270 - exocyst complex component 7

Symbol

Exoc7
Name

exocyst complex component 7
Synonyms

70kDa, Exo70, sec70

Feature Type

protein coding gene
IDs

MGI:1859270
NCBI Gene: 53413
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:116178823-116197574 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.11 cM, cytoband E2
Mapping Data

1 experiment

SNPs within 2kb

787 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859270	protein coding gene	Chr11:116178823-116198059 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019423	protein coding gene	Chr11:120392538-120412510 (-)
A/J	MGP_AJ_G0019392	protein coding gene	Chr11:115130204-115149562 (-)
AKR/J	MGP_AKRJ_G0019362	protein coding gene	Chr11:118558957-118578213 (-)
BALB/cJ	MGP_BALBcJ_G0019366	protein coding gene	Chr11:115539559-115559571 (-)
C3H/HeJ	MGP_C3HHeJ_G0019172	protein coding gene	Chr11:118911653-118931754 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019816	protein coding gene	Chr11:124085883-124105164 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017439	protein coding gene	Chr11:112139749-112160491 (-)
CAST/EiJ	MGP_CASTEiJ_G0018727	protein coding gene	Chr11:120274453-120296449 (-)
CBA/J	MGP_CBAJ_G0019144	protein coding gene	Chr11:128975674-128994958 (-)
DBA/2J	MGP_DBA2J_G0019255	protein coding gene	Chr11:114543837-114563450 (-)
FVB/NJ	MGP_FVBNJ_G0019247	protein coding gene	Chr11:114062451-114082368 (-)
LP/J	MGP_LPJ_G0019325	protein coding gene	Chr11:120771237-120791071 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019280	protein coding gene	Chr11:128049255-128069326 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019854	protein coding gene	Chr11:119217637-119238948 (-)
PWK/PhJ	MGP_PWKPhJ_G0018491	protein coding gene	Chr11:115878478-115899494 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018284	protein coding gene	Chr11:118970293-118991100 (-)
WSB/EiJ	MGP_WSBEiJ_G0018779	protein coding gene	Chr11:119185107-119204559 (-)

Human Ortholog

EXOC7, exocyst complex component 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EXOC7, exocyst complex component 7
Synonyms

2-5-3p, BLOM4, EX070, EXO70, Exo70p, EXOC1, NEDSEBA, YJL085W
Links

HGNC:23214

NCBI Gene ID: 23265

neXtProt AC: NX_Q9UPT5

UniProt: Q9UPT5
Chr Location

17q25.1; chr17:76081016-76121576 (-) GRCh38

MGI Vertebrate Homology

Exoc7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EXOC7
Gene Tree

Exoc7

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

Homozygous KO in spermatogonial stem cells affects spermatogenesis and leads to male sterility.

less

All GO Annotations

27
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

4
cDNA Data

89
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase exoc7

ZFIN exoc7

less

All Sequences

76
RefSeq

16
UniProt

9
CCDS

CCDS25664.1, CCDS48983.1, CCDS83935.1

Ensembl

ENSMUSG00000020792 (Evidence)
NCBI Gene

53413

			Length	Strain/Species	Flank
genomic	53413	NCBI Gene Model \| MGI Sequence Detail	18752	C57BL/6J	± kb
transcript	NM_001362838	RefSeq \| MGI Sequence Detail	3410	C57BL/6
polypeptide	O35250	UniProt \| EBI \| MGI Sequence Detail	697	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000007255 exocyst complex component 7

(term hierarchy)
PDB

2PFT
InterPro Domains

IPR016159 Cullin repeat-like-containing domain superfamily

IPR004140 Exocyst complex component Exo70

IPR046364 Exocyst complex subunit Exo70, C-terminal

less

All nucleic 90

cDNA 89

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 6
Earliest

J:82172 Davies PA, et al., A novel class of ligand-gated ion channel is activated by Zn2+. J Biol Chem. 2003 Jan 10;278(2):712-7
Latest

J:347251 Mikami N, et al., Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Exp Anim. 2024 Feb 7;

TSS for Exoc7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111903	Chr11:116197994-116198016 (-)	-431 bp
Tssr111902	Chr11:116197522-116197576 (-)	25 bp
Tssr111901	Chr11:116197501-116197517 (-)	65 bp
Tssr111900	Chr11:116191146-116191163 (-)	6,419 bp
Tssr111899	Chr11:116183301-116183302 (-)	14,272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24