Cldn7 MGI Mouse Gene Detail - MGI:1859285

Symbol

Cldn7
Name

claudin 7

Feature Type

protein coding gene
IDs

MGI:1859285
NCBI Gene: 53624
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:69855605-69858711 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.94 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

13 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859285	protein coding gene	Chr11:69855605-69858712 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018572	protein coding gene	Chr11:70454654-70457719 (+)
A/J	MGP_AJ_G0018540	protein coding gene	Chr11:67789360-67792425 (+)
AKR/J	MGP_AKRJ_G0018509	protein coding gene	Chr11:69809673-69812738 (+)
BALB/cJ	MGP_BALBcJ_G0018512	protein coding gene	Chr11:68118463-68121528 (+)
C3H/HeJ	MGP_C3HHeJ_G0018325	protein coding gene	Chr11:69847931-69852548 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018963	protein coding gene	Chr11:72580539-72583604 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016608	protein coding gene	Chr11:64714690-64717800 (+)
CAST/EiJ	MGP_CASTEiJ_G0017880	protein coding gene	Chr11:70091864-70094931 (+)
CBA/J	MGP_CBAJ_G0018297	protein coding gene	Chr11:75835253-75838318 (+)
DBA/2J	MGP_DBA2J_G0018407	protein coding gene	Chr11:67372206-67375272 (+)
FVB/NJ	MGP_FVBNJ_G0018397	protein coding gene	Chr11:67021146-67024211 (+)
LP/J	MGP_LPJ_G0018477	protein coding gene	Chr11:71039457-71042522 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018420	protein coding gene	Chr11:76426224-76429289 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019005	protein coding gene	Chr11:70083316-70086381 (+)
PWK/PhJ	MGP_PWKPhJ_G0017654	protein coding gene	Chr11:68025407-68028473 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017444	protein coding gene	Chr11:69901966-69905030 (+)
WSB/EiJ	MGP_WSBEiJ_G0017934	protein coding gene	Chr11:69747191-69750256 (+)

Human Ortholog

CLDN7, claudin 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLDN7, claudin 7
Synonyms

CEPTRL2, claudin-1, CLDN-7, CPETRL2, Hs.84359
Links

HGNC:2049

NCBI Gene ID: 1366

neXtProt AC: NX_O95471

UniProt: O95471
Chr Location

17p13.1; chr17:7259903-7263983 (-) GRCh38

MGI Vertebrate Homology

Cldn7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLDN7
Gene Tree

Cldn7

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Genomic Mutations

2 involving Cldn7
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

54
cDNA Data

170
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cldn7

ZFIN cldn7a, cldn7b

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All Sequences

50
RefSeq

4
UniProt

5
CCDS

CCDS24925.1

Ensembl

ENSMUSG00000018569 (Evidence)
NCBI Gene

53624

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018569	Ensembl Gene Model \| MGI Sequence Detail	3107	C57BL/6J	± kb
transcript	ENSMUST00000108597	Ensembl \| MGI Sequence Detail	913	Not Applicable
polypeptide	ENSMUSP00000104238	Ensembl \| MGI Sequence Detail	211	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005555 claudin-7

(term hierarchy)
InterPro Domains

IPR006187 Claudin

IPR003552 Claudin-7

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin

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All nucleic 177

cDNA 170

Primer pair 6

Other 1

Microarray probesets 3

Summaries

All 90

Developmental Gene Expression 32

Gene Ontology 12

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:337005 Ozekin YH, et al., Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity. Dev Dyn. 2023 Jun;252(6):713-727

TSS for Cldn7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102579	Chr11:69855584-69855637 (+)	6 bp
Tssr102580	Chr11:69856319-69856336 (+)	723 bp
Tssr102581	Chr11:69856422-69856447 (+)	830 bp
Tssr102582	Chr11:69856480-69856521 (+)	896 bp
Tssr102583	Chr11:69856552-69856567 (+)	955 bp
Tssr102584	Chr11:69856688-69856726 (+)	1,102 bp
Tssr3566	Chr11:69857700-69857701 (+)	2,096 bp
Tssr102585	Chr11:69857722-69857737 (+)	2,125 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24