Dnmt3l MGI Mouse Gene Detail - MGI:1859287 - DNA methyltransferase 3-like

Symbol

Dnmt3l
Name

DNA methyltransferase 3-like
Synonyms

D6Ertd14e, ecat7

Feature Type

protein coding gene
IDs

MGI:1859287
NCBI Gene: 54427
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:77878121-77899456 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

4 experiments

SNPs within 2kb

563 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859287	protein coding gene	Chr10:77877781-77899456 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017415	protein coding gene	Chr10:78452072-78477671 (+)
A/J	MGP_AJ_G0017393	protein coding gene	Chr10:75734010-75758464 (+)
AKR/J	MGP_AKRJ_G0017356	protein coding gene	Chr10:77761734-77783303 (+)
BALB/cJ	MGP_BALBcJ_G0017355	protein coding gene	Chr10:75907783-75930048 (+)
C3H/HeJ	MGP_C3HHeJ_G0017178	protein coding gene	Chr10:77844283-77868219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017811	protein coding gene	Chr10:81238456-81262344 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015502	protein coding gene	Chr10:72083678-72106331 (+)
CAST/EiJ	MGP_CASTEiJ_G0016748	protein coding gene	Chr10:78171989-78194632 (+)
CBA/J	MGP_CBAJ_G0017150	protein coding gene	Chr10:84315672-84354798 (+)
DBA/2J	MGP_DBA2J_G0017258	protein coding gene	Chr10:74975238-74999345 (+)
FVB/NJ	MGP_FVBNJ_G0017250	protein coding gene	Chr10:74160222-74182506 (+)
LP/J	MGP_LPJ_G0017329	protein coding gene	Chr10:78903732-78930803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017277	protein coding gene	Chr10:86313281-86338331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017853	protein coding gene	Chr10:77805437-77829942 (+)
PWK/PhJ	MGP_PWKPhJ_G0016530	protein coding gene	Chr10:74852028-74875728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016315	protein coding gene	Chr10:77023511-77048481 (+)
WSB/EiJ	MGP_WSBEiJ_G0016808	protein coding gene	Chr10:77777190-77801730 (+)

Human Ortholog

DNMT3L, DNA methyltransferase 3 like

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNMT3L, DNA methyltransferase 3 like
Links

HGNC:2980

NCBI Gene ID: 29947

neXtProt AC: NX_Q9UJW3

UniProt: Q9UJW3
Chr Location

21q22.3; chr21:44246339-44262216 (-) GRCh38

MGI Vertebrate Homology

Dnmt3l stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: DNMT3L
Gene Tree

Dnmt3l

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References

2 with disease annotations

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Phenotype Summary

29 phenotypes from 7 alleles in 7 genetic backgrounds
10 phenotypes from multigenic genotypes
1 images
89 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

29
Targeted

14
Transgenic

3
Genomic Mutations

4 involving Dnmt3l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.

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All GO Annotations

46
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1167
Tissues

199
cDNA Data

29
Literature Summary

69

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

67
RefSeq

12
UniProt

3
CCDS

CCDS23962.1, CCDS70061.1

Ensembl

ENSMUSG00000000730 (Evidence)
NCBI Gene

54427

			Length	Strain/Species	Flank
genomic	54427	NCBI Gene Model \| MGI Sequence Detail	21336	C57BL/6J	± kb
transcript	NM_001081695	RefSeq \| MGI Sequence Detail	1831	ZRU/MplStud
polypeptide	Q9CWR8	UniProt \| EBI \| MGI Sequence Detail	421	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006609 DNA (cytosine-5)-methyltransferase 3-like

(term hierarchy)
InterPro Domains

IPR025766 ADD domain

IPR049554 DNMT3, ADD domain, PHD zinc finger

IPR040552 DNMT3, cysteine rich ADD domain, GATA1-like zinc finger

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR011011 Zinc finger, FYVE/PHD-type

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All nucleic 47

Genomic 1

cDNA 30

Primer pair 15

Other 1

Microarray probesets 3

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MGI:1098798

Summaries

All 194

Developmental Gene Expression 69

Diseases 2

Gene Ontology 18

Phenotypes 89
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:347767 Wen Y, et al., hnRNPU is required for spermatogonial stem cell pool establishment in mice. Cell Rep. 2024 Apr 23;43(4):114113

TSS for Dnmt3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94307	Chr10:77885670-77885681 (+)	7,555 bp
Tssr94308	Chr10:77885694-77885701 (+)	7,577 bp
Tssr94309	Chr10:77885713-77885730 (+)	7,601 bp
Tssr94310	Chr10:77885768-77885796 (+)	7,661 bp
Tssr94311	Chr10:77886473-77886492 (+)	8,362 bp
Tssr94312	Chr10:77887898-77887904 (+)	9,780 bp
Tssr94313	Chr10:77890659-77890670 (+)	12,544 bp
Tssr94314	Chr10:77890688-77890710 (+)	12,578 bp
Tssr94315	Chr10:77890714-77890746 (+)	12,609 bp
Tssr94316	Chr10:77891161-77891199 (+)	13,059 bp
Tssr94317	Chr10:77893111-77893122 (+)	14,996 bp
Tssr94318	Chr10:77893132-77893137 (+)	15,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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