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Asah2 Gene Detail
Summary
  • Symbol
    Asah2
  • Name
    N-acylsphingosine amidohydrolase 2
  • Synonyms
    neutral/alkaline ceramidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859310
    NCBI Gene: 54447
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:31962046-32080540 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 26.58 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2929 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859310
 protein coding gene Chr19:31959997-32085611 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025038
 protein coding gene Chr19:30600078-30682589 (-)
A/J MGP_AJ_G0025015
 protein coding gene Chr19:29071980-29145499 (-)
AKR/J MGP_AKRJ_G0024983
 protein coding gene Chr19:30100370-30173697 (-)
BALB/cJ MGP_BALBcJ_G0025014
 protein coding gene Chr19:29119668-29198221 (-)
C3H/HeJ MGP_C3HHeJ_G0024770
 protein coding gene Chr19:30085054-30162200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025455
 protein coding gene Chr19:31438910-31526839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022874
 protein coding gene Chr19:28994995-29062840 (-)
CAST/EiJ MGP_CASTEiJ_G0024241
 protein coding gene Chr19:29968618-30059573 (-)
CBA/J MGP_CBAJ_G0024748
 protein coding gene Chr19:32900122-32990291 (-)
DBA/2J MGP_DBA2J_G0024880
 protein coding gene Chr19:29000828-29075458 (-)
FVB/NJ MGP_FVBNJ_G0024842
 protein coding gene Chr19:28824006-28900790 (-)
LP/J MGP_LPJ_G0024965
 protein coding gene Chr19:30608588-30683713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024869
 protein coding gene Chr19:32814108-32895315 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025510
 protein coding gene Chr19:30134655-30213027 (-)
PWK/PhJ MGP_PWKPhJ_G0023989
 protein coding gene Chr19:28692228-28767069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023793
 protein coding gene Chr19:29478199-29548237 (-)
WSB/EiJ MGP_WSBEiJ_G0024307
 protein coding gene Chr19:30171565-30252383 (-)



Homology
more
  • Human Ortholog
    ASAH2, N-acylsphingosine amidohydrolase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASAH2, N-acylsphingosine amidohydrolase 2
  • Synonyms
    BCDase, HNAC1, LCDase, N-CDase, NCDase
  • Links
    NCBI Gene ID: 56624
    neXtProt AC: NX_Q9NR71
    UniProt: Q9NR71

  • Chr Location
    10q11.23; chr10:50182778-50279720 (-)  GRCh38
  • Human Ortholog
    ASAH2B, N-acylsphingosine amidohydrolase 2B
  • Synonyms
    ASAH2C, ASAH2L, bA449O16.3, bA98I6.3
  • Links
    NCBI Gene ID: 653308
    neXtProt AC: NX_P0C7U1
    UniProt: P0C7U1

  • Chr Location
    10q11.23; chr10:50739318-50816495 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are defective in the intestinal digestion of dietary ceramide but exhibit a normal life span with no obvious abnormalities or significant alterations in total ceramide levels in major organ tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    97
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54447 NCBI Gene Model | MGI Sequence Detail 118495 C57BL/6J ±  kb
transcript NM_018830 RefSeq | MGI Sequence Detail 4835 Not Specified  
polypeptide Q9JHE3 UniProt | EBI | MGI Sequence Detail 756 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147579
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 14
    Phenotypes 11
  • Earliest
    J:61655 Tani M, et al., Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000 Apr 14;275(15):11229-34
  • Latest
    J:344839 Sun R, et al., Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages. Nat Commun. 2024 Feb 1;15(1):966
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory