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Nfat5 Gene Detail
Summary
  • Symbol
    Nfat5
  • Name
    nuclear factor of activated T cells 5
  • Synonyms
    B130038B15Rik, mKIAA0827, nfatz, OREBP, TonEBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859333
    NCBI Gene: 54446
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:108020102-108106149 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.93 cM, cytoband D2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1215 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859333
 protein coding gene Chr8:108020072-108106149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034099
 protein coding gene Chr8:109738436-109835699 (+)
A/J MGP_AJ_G0034079
 protein coding gene Chr8:105325609-105412322 (+)
AKR/J MGP_AKRJ_G0034005
 protein coding gene Chr8:108400050-108488955 (+)
BALB/cJ MGP_BALBcJ_G0034072
 protein coding gene Chr8:105533395-105620925 (+)
C3H/HeJ MGP_C3HHeJ_G0033784
 protein coding gene Chr8:109124724-109217597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034592
 protein coding gene Chr8:113713498-113819721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031534
 protein coding gene Chr8:98421677-98507762 (+)
CAST/EiJ MGP_CASTEiJ_G0033111
 protein coding gene Chr8:108662807-108758057 (+)
CBA/J MGP_CBAJ_G0033757
 protein coding gene Chr8:117431716-117519673 (+)
DBA/2J MGP_DBA2J_G0033912
 protein coding gene Chr8:104653203-104740600 (+)
FVB/NJ MGP_FVBNJ_G0033857
 protein coding gene Chr8:103596725-103685217 (+)
LP/J MGP_LPJ_G0034003
 protein coding gene Chr8:109927612-110020572 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033902
 protein coding gene Chr8:120549675-120662787 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034610
 protein coding gene Chr8:108339963-108429878 (+)
PWK/PhJ MGP_PWKPhJ_G0032813
 protein coding gene Chr8:104074352-104162441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032652
 protein coding gene Chr8:107045001-107137137 (+)
WSB/EiJ MGP_WSBEiJ_G0033226
 protein coding gene Chr8:109051081-109145083 (+)



Homology
more
  • Human Ortholog
    NFAT5, nuclear factor of activated T cells 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFAT5, nuclear factor of activated T cells 5
  • Synonyms
    NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
  • Links
    NCBI Gene ID: 10725
    neXtProt AC: NX_O94916
    UniProt: O94916

  • Chr Location
    16q22.1; chr16:69565094-69704666 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 7 alleles in 7 genetic backgrounds
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one of several knock-out allele exhibit lethality between E14.5 and E17.5 as well as around P10 with kidney, cardiac or immune defects depending on the allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    190
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003847 Ensembl Gene Model | MGI Sequence Detail 86048 C57BL/6J ±  kb
    transcript ENSMUST00000169453 Ensembl | MGI Sequence Detail 13380 Not Applicable  
    polypeptide ENSMUSP00000127784 Ensembl | MGI Sequence Detail 1552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011163 nuclear factor of activated T-cells 5
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR015646 Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain, DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    • GlyGen
      Q9WV30 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2142481, MGI:2442693
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 16
      Gene Ontology 13
      Phenotypes 58
    • Earliest
      J:62063 Lopez-Rodriguez C, et al., NF-AT5: the NF-AT family of transcription factors expands in a new direction. Cold Spring Harb Symp Quant Biol. 1999;64:517-26
    • Latest
      J:346645 Couasnay G, et al., A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc. Development. 2024 Mar 15;151(6):dev202354
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory