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Mkrn1 Gene Detail
Summary
  • Symbol
    Mkrn1
  • Name
    makorin, ring finger protein, 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859353
    NCBI Gene: 54484
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:39374738-39397396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 18.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859353
 protein coding gene Chr6:39374738-39400480 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030597
 protein coding gene Chr6:37774138-37802954 (-)
A/J MGP_AJ_G0030570
 protein coding gene Chr6:36125916-36148803 (-)
AKR/J MGP_AKRJ_G0030497
 protein coding gene Chr6:37279366-37304450 (-)
BALB/cJ MGP_BALBcJ_G0030580
 protein coding gene Chr6:36345370-36370226 (-)
C3H/HeJ MGP_C3HHeJ_G0030293
 protein coding gene Chr6:37293766-37320651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031034
 protein coding gene Chr6:38702394-38733798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028246
 protein coding gene Chr6:34023446-34046235 (-)
CAST/EiJ MGP_CASTEiJ_G0029695
 protein coding gene Chr6:37197094-37222803 (-)
CBA/J MGP_CBAJ_G0030271
 protein coding gene Chr6:40228995-40270040 (-)
DBA/2J MGP_DBA2J_G0030415
 protein coding gene Chr6:35949905-35972033 (-)
FVB/NJ MGP_FVBNJ_G0030369
 protein coding gene Chr6:35735940-35759937 (-)
LP/J MGP_LPJ_G0030502
 protein coding gene Chr6:37805229-37832210 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030405
 protein coding gene Chr6:42564338-42596583 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031064
 protein coding gene Chr6:37227452-37253112 (-)
PWK/PhJ MGP_PWKPhJ_G0029409
 protein coding gene Chr6:35631110-35654393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029245
 protein coding gene Chr6:36953210-36977805 (-)
WSB/EiJ MGP_WSBEiJ_G0029771
 protein coding gene Chr6:37172685-37201930 (-)



Homology
more
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKRN1, makorin ring finger protein 1
  • Synonyms
    RNF61
  • Links
    NCBI Gene ID: 23608
    neXtProt AC: NX_Q9UHC7
    UniProt: Q9UHC7

  • Chr Location
    7q34; chr7:140453033-140479569 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a gene-trapped allele are viable and fertile, and show normal kidney morphology, eyelid development, and skeletal morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    76
  • cDNA Data
    17
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029922 Ensembl Gene Model | MGI Sequence Detail 22659 C57BL/6J ±  kb
transcript ENSMUST00000031985 Ensembl | MGI Sequence Detail 3046 Not Applicable  
polypeptide ENSMUSP00000031985 Ensembl | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 11
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:62532 Gray TA, et al., The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics. 2000 May 15;66(1):76-86
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory