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Hpgds Gene Detail
Summary
  • Symbol
    Hpgds
  • Name
    hematopoietic prostaglandin D synthase
  • Synonyms
    H-PGDS, Ptgds2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859384
    NCBI Gene: 54486
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:65094277-65121892 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.11 cM, cytoband D-E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    852 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859384
 protein coding gene Chr6:65094019-65121960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030830
 protein coding gene Chr6:65043221-65070730 (-)
A/J MGP_AJ_G0030797
 protein coding gene Chr6:62196132-62223709 (-)
AKR/J MGP_AKRJ_G0030725
 protein coding gene Chr6:64178379-64205885 (-)
BALB/cJ MGP_BALBcJ_G0030808
 protein coding gene Chr6:62602914-62630959 (-)
C3H/HeJ MGP_C3HHeJ_G0030904
 protein coding gene Chr6:120027063-120054744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031266
 protein coding gene Chr6:66532342-66562917 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028459
 protein coding gene Chr6:59540822-59567104 (-)
CAST/EiJ MGP_CASTEiJ_G0029920
 protein coding gene Chr6:64440811-64471775 (-)
CBA/J MGP_CBAJ_G0030495
 protein coding gene Chr6:69257784-69284676 (-)
DBA/2J MGP_DBA2J_G0030647
 protein coding gene Chr6:61893107-61920637 (-)
FVB/NJ MGP_FVBNJ_G0030600
 protein coding gene Chr6:61426887-61454669 (-)
LP/J MGP_LPJ_G0030731
 protein coding gene Chr6:64994162-65021678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030635
 protein coding gene Chr6:73020842-73049313 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031292
 protein coding gene Chr6:64131320-64158765 (-)
PWK/PhJ MGP_PWKPhJ_G0029635
 protein coding gene Chr6:61062214-61090197 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029463
 protein coding gene Chr6:63659454-63689603 (-)
WSB/EiJ MGP_WSBEiJ_G0030002
 protein coding gene Chr6:64420976-64448665 (-)



Homology
more
  • Human Ortholog
    HPGDS, hematopoietic prostaglandin D synthase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPGDS, hematopoietic prostaglandin D synthase
  • Synonyms
    GSTS, GSTS1, GSTS1-1, PGD2, PGDS
  • Links
    NCBI Gene ID: 27306
    neXtProt AC: NX_O60760
    UniProt: O60760

  • Chr Location
    4q22.3; chr4:94298535-94342876 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display increased IL-2 synthesis and heightened proliferation of ex vivo lymph node cultures in response to BSA or concanavalin A challenge, and fail to resolve a Th1-driven delayed type hypersensitivity reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    108
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029919 Ensembl Gene Model | MGI Sequence Detail 27616 C57BL/6J ±  kb
    transcript ENSMUST00000031982 Ensembl | MGI Sequence Detail 3476 Not Applicable  
    polypeptide ENSMUSP00000031982 Ensembl | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 13
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 39
    • Earliest
      J:62511 Kanaoka Y, et al., Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Eur J Biochem. 2000 Jun;267(11):3315-22
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory