Acrbp MGI Mouse Gene Detail - MGI:1859515 - proacrosin binding protein

Symbol

Acrbp
Name

proacrosin binding protein
Synonyms

OY-TES-1, sp32

Feature Type

protein coding gene
IDs

MGI:1859515
NCBI Gene: 54137
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:125026890-125040228 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

504 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859515	protein coding gene	Chr6:125026652-125040230 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031283	protein coding gene	Chr6:128375170-128388727 (+)
A/J	MGP_AJ_G0031253	protein coding gene	Chr6:123532235-123546398 (+)
AKR/J	MGP_AKRJ_G0031181	protein coding gene	Chr6:126908306-126921952 (+)
BALB/cJ	MGP_BALBcJ_G0031261	protein coding gene	Chr6:123128940-123142515 (+)
C3H/HeJ	MGP_C3HHeJ_G0030984	protein coding gene	Chr6:126962538-126977605 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031717	protein coding gene	Chr6:131753372-131766964 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028867	protein coding gene	Chr6:120737035-120750928 (+)
CAST/EiJ	MGP_CASTEiJ_G0030365	protein coding gene	Chr6:127169637-127183493 (+)
CBA/J	MGP_CBAJ_G0030945	protein coding gene	Chr6:136796488-136818021 (+)
DBA/2J	MGP_DBA2J_G0031101	protein coding gene	Chr6:122463502-122477256 (+)
FVB/NJ	MGP_FVBNJ_G0031051	protein coding gene	Chr6:121369941-121384075 (+)
LP/J	MGP_LPJ_G0031181	protein coding gene	Chr6:128536885-128552202 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031089	protein coding gene	Chr6:140844221-140858761 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031752	protein coding gene	Chr6:126798885-126812492 (+)
PWK/PhJ	MGP_PWKPhJ_G0030080	protein coding gene	Chr6:120702997-120716819 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029909	protein coding gene	Chr6:124881898-124897705 (+)
WSB/EiJ	MGP_WSBEiJ_G0030450	protein coding gene	Chr6:127167989-127182804 (+)

Human Ortholog

ACRBP, acrosin binding protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACRBP, acrosin binding protein
Synonyms

CT23, OY-TES-1, SP32
Links

HGNC:17195

NCBI Gene ID: 84519

neXtProt AC: NX_Q8NEB7

UniProt: Q8NEB7
Chr Location

12p13.31; chr12:6638075-6647433 (-) GRCh38

MGI Vertebrate Homology

Acrbp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACRBP
Gene Tree

Acrbp

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced male fertility associated with aberrant formation of the acrosomal granule, a fragmented acrosome structure, an abnormally condensed nuclear structure, and decreased sperm motility.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

40
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acrbp.2, acrbpl

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS20542.1, CCDS51910.1

Ensembl

ENSMUSG00000072770 (Evidence)
NCBI Gene

54137

			Length	Strain/Species	Flank
genomic	54137	NCBI Gene Model \| MGI Sequence Detail	13339	C57BL/6J	± kb
transcript	NM_016845	RefSeq \| MGI Sequence Detail	1913	C57BL/6
polypeptide	Q3V140	UniProt \| EBI \| MGI Sequence Detail	540	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003653 acrosin-binding protein

(term hierarchy)
InterPro Domains

IPR009865 Proacrosin binding sp32

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All nucleic 41

cDNA 40

Primer pair 1

Microarray probesets 6

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 7
Earliest

J:71436 Baba T, et al., An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J Biol Chem. 1994 Apr 1;269(13):10133-40
Latest

J:294381 Nagashima K, et al., Behavior of ACRBP-deficient mouse sperm in the female reproductive tract. J Reprod Dev. 2019 Apr 12;65(2):97-102

TSS for Acrbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58892	Chr6:125026866-125026910 (+)	-2 bp
Tssr58893	Chr6:125026915-125026934 (+)	35 bp
Tssr58894	Chr6:125026935-125026949 (+)	52 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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