Praf2 MGI Mouse Gene Detail - MGI:1859607

Symbol

Praf2
Name

PRA1 domain family 2
Synonyms

DXImx39e, JM4, Sfc20

Feature Type

protein coding gene
IDs

MGI:1859607
NCBI Gene: 54637
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:7594810-7597302 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 3.48 cM
Mapping Data

4 experiments

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859607	protein coding gene	ChrX:7594678-7597303 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035521	protein coding gene	ChrX:2343272-2345897 (+)
A/J	MGP_AJ_G0035499	protein coding gene	ChrX:2305679-2308272 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0035495	protein coding gene	ChrX:2327280-2329905 (+)
C3H/HeJ	MGP_C3HHeJ_G0035203	protein coding gene	ChrX:2389524-2392897 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036019	protein coding gene	ChrX:2424723-2430514 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032895	protein coding gene	ChrX:1872047-1874665 (+)
CAST/EiJ	MGP_CASTEiJ_G0034504	protein coding gene	ChrX:2281021-2283388 (+)
CBA/J	MGP_CBAJ_G0035173	protein coding gene	ChrX:2550252-2553365 (+)
DBA/2J	MGP_DBA2J_G0035330	protein coding gene	ChrX:2331477-2334102 (+)
FVB/NJ	MGP_FVBNJ_G0035277	protein coding gene	ChrX:2288180-2291265 (+)
LP/J	MGP_LPJ_G0035408	protein coding gene	ChrX:2365689-2369130 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035317	protein coding gene	ChrX:2503380-2520367 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036037	protein coding gene	ChrX:2330047-2333557 (+)
PWK/PhJ	MGP_PWKPhJ_G0034205	protein coding gene	ChrX:2263924-2266548 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034043	protein coding gene	ChrX:2296143-2298773 (+)
WSB/EiJ	MGP_WSBEiJ_G0034627	protein coding gene	ChrX:2336999-2340689 (+)

Human Ortholog

PRAF2, PRA1 domain family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRAF2, PRA1 domain family member 2
Synonyms

JM4, Yip6a
Links

HGNC:28911

NCBI Gene ID: 11230

neXtProt AC: NX_O60831

UniProt: O60831
Chr Location

Xp11.23; chrX:49071161-49074002 (-) GRCh38

MGI Vertebrate Homology

Praf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRAF2
Gene Tree

Praf2

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

3
cDNA Data

45
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN praf2

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS29971.1

Ensembl

ENSMUSG00000031149 (Evidence)
NCBI Gene

54637

			Length	Strain/Species	Flank
genomic	54637	NCBI Gene Model \| MGI Sequence Detail	2493	C57BL/6J	± kb
transcript	NM_138602	RefSeq \| MGI Sequence Detail	1206	ZRU/MplStud
polypeptide	Q9JIG8	UniProt \| EBI \| MGI Sequence Detail	178	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013168 PRA1 family protein 2

(term hierarchy)
InterPro Domains

IPR004895 Prenylated rab acceptor PRA1
GlyGen

Q9JIG8 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

Genomic 5

cDNA 45

Microarray probesets 4

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MGI:2140183, MGI:2148054

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Praf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160417	ChrX:7594670-7594681 (+)	-134 bp
Tssr160418	ChrX:7594738-7594749 (+)	-66 bp
Tssr160419	ChrX:7594773-7594784 (+)	-31 bp
Tssr160420	ChrX:7594785-7594818 (+)	-8 bp
Tssr160421	ChrX:7594822-7594827 (+)	15 bp
Tssr160422	ChrX:7596112-7596135 (+)	1,314 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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