Sfmbt1 MGI Mouse Gene Detail - MGI:1859609 - Scm-like with four mbt domains 1

Symbol

Sfmbt1
Name

Scm-like with four mbt domains 1
Synonyms

4930442N21Rik, 9330180L21Rik, Smr

Feature Type

protein coding gene
IDs

MGI:1859609
NCBI Gene: 54650
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:30436806-30544678 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.99 cM
Mapping Data

4 experiments

SNPs within 2kb

1816 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859609	protein coding gene	Chr14:30436806-30544678 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021107	protein coding gene	Chr14:23851422-23960073 (+)
A/J	MGP_AJ_G0021055	protein coding gene	Chr14:22967825-23075287 (+)
AKR/J	MGP_AKRJ_G0021032	protein coding gene	Chr14:24078773-24184667 (+)
BALB/cJ	MGP_BALBcJ_G0021059	protein coding gene	Chr14:23068162-23173595 (+)
C3H/HeJ	MGP_C3HHeJ_G0020842	protein coding gene	Chr14:23937794-24046052 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021491	protein coding gene	Chr14:24808883-24920308 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019054	protein coding gene	Chr14:23025354-23134481 (+)
CAST/EiJ	MGP_CASTEiJ_G0020367	protein coding gene	Chr14:23688711-23793801 (+)
CBA/J	MGP_CBAJ_G0020809	protein coding gene	Chr14:25760126-25875762 (+)
DBA/2J	MGP_DBA2J_G0020931	protein coding gene	Chr14:22999749-23099253 (+)
FVB/NJ	MGP_FVBNJ_G0020915	protein coding gene	Chr14:22954743-23057159 (+)
LP/J	MGP_LPJ_G0021000	protein coding gene	Chr14:24177517-24291077 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020941	protein coding gene	Chr14:25041911-25155501 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021524	protein coding gene	Chr14:23823289-23936014 (+)
PWK/PhJ	MGP_PWKPhJ_G0020115	protein coding gene	Chr14:22435449-22547448 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019939	protein coding gene	Chr14:23417456-23516938 (+)
WSB/EiJ	MGP_WSBEiJ_G0020422	protein coding gene	Chr14:23888702-23996375 (+)

Human Ortholog

SFMBT1, Scm like with four mbt domains 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFMBT1, Scm like with four mbt domains 1
Synonyms

hSFMBT, RU1, SFMBT
Links

HGNC:20255

NCBI Gene ID: 51460

neXtProt AC: NX_Q9UHJ3

UniProt: Q9UHJ3
Chr Location

3p21.1; chr3:52903572-53046750 (-) GRCh38

MGI Vertebrate Homology

Sfmbt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFMBT1
Gene Tree

Sfmbt1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

15
cDNA Data

71
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfmbt1

ZFIN sfmbt1

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All Sequences

81
RefSeq

22
UniProt

7
CCDS

CCDS26897.1

Ensembl

ENSMUSG00000006527 (Evidence)
NCBI Gene

54650

			Length	Strain/Species	Flank
genomic	54650	NCBI Gene Model \| MGI Sequence Detail	107873	C57BL/6J	± kb
transcript	NM_001166532	RefSeq \| MGI Sequence Detail	7837	ZRU/MplStud
polypeptide	Q9JMD1	UniProt \| EBI \| MGI Sequence Detail	863	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000029760 Scm-like with four MBT domains protein 1

(term hierarchy)
InterPro Domains

IPR004092 Mbt repeat

IPR050548 Polycomb group and chromatin remodeling factors

IPR037604 Scm-like with four MBT domains protein 1/2, SAM domain

IPR047352 Scm-like with four MBT domains protein 1, second MBT repeat

IPR047351 Scm-like with four MBT domains protein 1, third MBT repeat

IPR021987 SLED domain

IPR038348 SLED domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 74

Genomic 2

cDNA 71

Primer pair 1

Microarray probesets 9

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MGI:1924518, MGI:1925411, MGI:2145571

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 11
Earliest

J:62166 Usui H, et al., Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. Gene. 2000 May 2;248(1-2):127-35
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sfmbt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124849	Chr14:30437556-30437598 (+)	771 bp
Tssr124850	Chr14:30437603-30437621 (+)	806 bp
Tssr124851	Chr14:30437645-30437698 (+)	866 bp
Tssr124852	Chr14:30437739-30437751 (+)	939 bp
Tssr124853	Chr14:30438334-30438372 (+)	1,547 bp
Tssr124854	Chr14:30438835-30438839 (+)	2,031 bp
Tssr124855	Chr14:30441785-30441789 (+)	4,981 bp
Tssr124856	Chr14:30454834-30454839 (+)	18,031 bp
Tssr124857	Chr14:30465760-30465765 (+)	28,957 bp
Tssr124858	Chr14:30541129-30541154 (+)	104,336 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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