Gpkow Gene Detail

Summary

• Symbol
  Gpkow
• Name
  G patch domain and KOW motifs
• Synonyms
  DXErtd697e, DXImx41e, mT54, T54

• Feature Type
  protein coding gene
• IDs
  MGI:1859610
  NCBI Gene: 209416
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  ChrX:7563373-7576500 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 3.47 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  374 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859610	protein coding gene	ChrX:7563370-7576501 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035519	protein coding gene	ChrX:2310405-2323533 (+)
A/J	MGP_AJ_G0035497	protein coding gene	ChrX:2274088-2287045 (+)
AKR/J	MGP_AKRJ_G0035430	protein coding gene	ChrX:2383634-2398408 (+)
BALB/cJ	MGP_BALBcJ_G0035493	protein coding gene	ChrX:2293743-2307465 (+)
C3H/HeJ	MGP_C3HHeJ_G0035201	protein coding gene	ChrX:2345631-2369640 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036017	protein coding gene	ChrX:2387872-2403263 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032893	protein coding gene	ChrX:1838286-1851524 (+)
CAST/EiJ	MGP_CASTEiJ_G0034502	protein coding gene	ChrX:2245142-2262565 (+)
CBA/J	MGP_CBAJ_G0035171	protein coding gene	ChrX:2511095-2528622 (+)
DBA/2J	MGP_DBA2J_G0035328	protein coding gene	ChrX:2297059-2310660 (+)
FVB/NJ	MGP_FVBNJ_G0035275	protein coding gene	ChrX:2256503-2269540 (+)
LP/J	MGP_LPJ_G0035406	protein coding gene	ChrX:2333758-2336446 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035315	protein coding gene	ChrX:2472018-2485063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036035	protein coding gene	ChrX:2298357-2311886 (+)
PWK/PhJ	MGP_PWKPhJ_G0034203	protein coding gene	ChrX:2232308-2245912 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034041	protein coding gene	ChrX:2273706-2278162 (+)
WSB/EiJ	MGP_WSBEiJ_G0034625	protein coding gene	ChrX:2301637-2316362 (+)

Homology

• Human Ortholog
  GPKOW, G-patch domain and KOW motifs

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GPKOW, G-patch domain and KOW motifs
  
• Synonyms
  GPATC5, GPATCH5, Mos2, Spp2, T54
• Links
  HGNC:30677

  NCBI Gene ID: 27238

  neXtProt AC: NX_Q92917

  UniProt: Q92917

  
  
• Chr Location
  Xp11.23; chrX:49113407-49123735 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gpkow stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: GPKOW
• Gene Tree
  Gpkow
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  4

Expression

• Assay Results
  706
• cDNA Data
  71

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gpkow
  ZFIN gpkow

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS29969.2

• Ensembl
  ENSMUSG00000031148 (Evidence)
• NCBI Gene
  209416

Representative Sequences			Length	Strain/Species
genomic	209416	NCBI Gene Model | MGI Sequence Detail	13128	C57BL/6J
transcript	NM_173747	RefSeq | MGI Sequence Detail	3591	ZRU/MplStud
polypeptide	Q56A08	UniProt | EBI | MGI Sequence Detail	488	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000029516 G-patch domain and KOW motifs-containing protein
  (term hierarchy)
• InterPro Domains
  IPR000467 G-patch domain
  IPR041993 G-patch domain and KOW motifs-containing protein, KOW 1
  IPR041994 G-patch domain and KOW motifs-containing protein, KOW 2
  IPR005824 KOW
  IPR014722 Large ribosomal subunit protein uL2, domain 2
  IPR045166 Pre-mRNA-splicing factor Spp2-like
  IPR026822 Spp2/MOS2, G-patch domain
  IPR008991 Translation protein SH3-like domain superfamily

Molecular
Reagents

• All nucleic 78

  Genomic 5

  cDNA 72

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1277185

References

• Summaries
  All 31

  Gene Ontology 4

  Phenotypes 1
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Gpkow:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160411	ChrX:7563403-7563426 (+)	42 bp
Tssr160412	ChrX:7563427-7563458 (+)	70 bp