Golga4 MGI Mouse Gene Detail - MGI:1859646

Symbol

Golga4
Name

golgin A4
Synonyms

golgin-245, Olp-1

Feature Type

protein coding gene
IDs

MGI:1859646
NCBI Gene: 54214
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:118335335-118411587 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 70.23 cM
Mapping Data

1 experiment

SNPs within 2kb

1573 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859646	protein coding gene	Chr9:118335280-118411587 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035406	protein coding gene	Chr9:121187629-121267432 (+)
A/J	MGP_AJ_G0035386	protein coding gene	Chr9:116711103-116788702 (+)
AKR/J	MGP_AKRJ_G0035319	protein coding gene	Chr9:119725363-119806498 (+)
BALB/cJ	MGP_BALBcJ_G0035382	protein coding gene	Chr9:116576078-116652430 (+)
C3H/HeJ	MGP_C3HHeJ_G0035090	protein coding gene	Chr9:120201725-120282250 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035905	protein coding gene	Chr9:124501163-124582498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032788	protein coding gene	Chr9:113915752-113995845 (+)
CAST/EiJ	MGP_CASTEiJ_G0034394	protein coding gene	Chr9:120154506-120238202 (+)
CBA/J	MGP_CBAJ_G0035057	protein coding gene	Chr9:129177721-129266628 (+)
DBA/2J	MGP_DBA2J_G0035216	protein coding gene	Chr9:116155196-116231777 (+)
FVB/NJ	MGP_FVBNJ_G0035163	protein coding gene	Chr9:114990564-115067329 (+)
LP/J	MGP_LPJ_G0035295	protein coding gene	Chr9:121535535-121615504 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035204	protein coding gene	Chr9:130221561-130305258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035924	protein coding gene	Chr9:120108141-120191260 (+)
PWK/PhJ	MGP_PWKPhJ_G0034101	protein coding gene	Chr9:116536793-116614166 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033935	protein coding gene	Chr9:120193756-120275191 (+)
WSB/EiJ	MGP_WSBEiJ_G0034515	protein coding gene	Chr9:120006899-120087466 (+)

Human Ortholog

GOLGA4, golgin A4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOLGA4, golgin A4
Synonyms

CRPF46, GCP2, GOLG, MU-RMS-40.18, p230
Links

HGNC:4427

NCBI Gene ID: 2803

neXtProt AC: NX_Q13439

UniProt: Q13439
Chr Location

3p22.2; chr3:37243191-37366879 (+) GRCh38

MGI Vertebrate Homology

Golga4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOLGA4
Gene Tree

Golga4

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

4
Gene trapped

21
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

105 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show normal male fertility, testis size, sperm count, male germ cell development and spermiogenesis.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

97
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase golga4

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All Sequences

140
RefSeq

63
UniProt

14
CCDS

CCDS40801.1

Ensembl

ENSMUSG00000038708 (Evidence)
NCBI Gene

54214

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038708	Ensembl Gene Model \| MGI Sequence Detail	76253	C57BL/6J	± kb
transcript	ENSMUST00000084820	Ensembl \| MGI Sequence Detail	7583	Not Applicable
polypeptide	ENSMUSP00000081880	Ensembl \| MGI Sequence Detail	2238	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000008133 golgin subfamily A member 4

(term hierarchy)
InterPro Domains

IPR000237 GRIP domain

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All nucleic 19

cDNA 17

Primer pair 1

Other 1

Microarray probesets 5

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MGI:2142994, MGI:2143202

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 11
Earliest

J:44309 Gay D, et al., OlP-1, a novel protein that distinguishes early oligodendrocyte precursors. J Neurosci Res. 1997 Nov 15;50(4):591-604
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Golga4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87635	Chr9:118335294-118335357 (+)	-9 bp
Tssr87636	Chr9:118341980-118342002 (+)	6,656 bp
Tssr87637	Chr9:118348644-118348648 (+)	13,311 bp
Tssr87638	Chr9:118367943-118367973 (+)	32,623 bp
Tssr87639	Chr9:118385617-118385635 (+)	50,291 bp
Tssr87640	Chr9:118387096-118387109 (+)	51,768 bp
Tssr87641	Chr9:118387504-118387507 (+)	52,171 bp
Tssr87642	Chr9:118389422-118389440 (+)	54,096 bp
Tssr87643	Chr9:118399583-118399590 (+)	64,252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24