Adgrg3 MGI Mouse Gene Detail - MGI:1859670 - adhesion G protein-coupled receptor G3

Symbol

Adgrg3
Name

adhesion G protein-coupled receptor G3
Synonyms

A030001G24Rik, Gpr97, Pb99

Feature Type

protein coding gene
IDs

MGI:1859670
NCBI Gene: 54672
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:95744320-95771878 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 47.12 cM
Mapping Data

3 experiments

SNPs within 2kb

894 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859670	protein coding gene	Chr8:95743742-95771878 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033977	protein coding gene	Chr8:96471600-96501189 (+)
A/J	MGP_AJ_G0033960	protein coding gene	Chr8:92708288-92739264 (+)
AKR/J	MGP_AKRJ_G0033886	protein coding gene	Chr8:95235423-95265452 (+)
BALB/cJ	MGP_BALBcJ_G0033952	protein coding gene	Chr8:92791227-92818082 (+)
C3H/HeJ	MGP_C3HHeJ_G0033662	protein coding gene	Chr8:95952998-95982234 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034473	protein coding gene	Chr8:99983655-100012228 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031414	protein coding gene	Chr8:86509584-86537102 (+)
CAST/EiJ	MGP_CASTEiJ_G0032994	protein coding gene	Chr8:95556827-95584403 (+)
CBA/J	MGP_CBAJ_G0033638	protein coding gene	Chr8:103291785-103327503 (+)
DBA/2J	MGP_DBA2J_G0033792	protein coding gene	Chr8:92195566-92222953 (+)
FVB/NJ	MGP_FVBNJ_G0033739	protein coding gene	Chr8:91139615-91168552 (+)
LP/J	MGP_LPJ_G0033884	protein coding gene	Chr8:96613736-96641675 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033781	protein coding gene	Chr8:105562653-105599269 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034491	protein coding gene	Chr8:95399360-95427384 (+)
PWK/PhJ	MGP_PWKPhJ_G0032696	protein coding gene	Chr8:91557316-91585934 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032533	protein coding gene	Chr8:94253157-94283027 (+)
WSB/EiJ	MGP_WSBEiJ_G0033106	protein coding gene	Chr8:95937230-95968337 (+)

Human Ortholog

ADGRG3, adhesion G protein-coupled receptor G3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRG3, adhesion G protein-coupled receptor G3
Synonyms

GPR97, PB99, PGR26
Links

HGNC:13728

NCBI Gene ID: 222487

neXtProt AC: NX_Q86Y34

UniProt: Q86Y34
Chr Location

16q21; chr16:57665629-57689378 (+) GRCh38

MGI Vertebrate Homology

Adgrg3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRG3
Gene Tree

Adgrg3

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display normal B and T cell development.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

32
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

9
UniProt

4
CCDS

CCDS22554.1

Ensembl

ENSMUSG00000060470 (Evidence)
NCBI Gene

54672

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060470	Ensembl Gene Model \| MGI Sequence Detail	27559	C57BL/6J	± kb
transcript	ENSMUST00000051259	Ensembl \| MGI Sequence Detail	2439	Not Applicable
polypeptide	ENSMUSP00000051079	Ensembl \| MGI Sequence Detail	542	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031123 adhesion G protein-coupled receptor G3

(term hierarchy)
InterPro Domains

IPR046338 GAIN domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif
GlyGen

Q8R0T6 4 sites

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All nucleic 33

cDNA 33

Microarray probesets 1

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MGI:2142778, MGI:2441770

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:62512 Sleckman BP, et al., Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol. 2000 Jun;20(12):4405-10
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Adgrg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78958	Chr8:95744335-95744354 (+)	25 bp
Tssr78959	Chr8:95744362-95744383 (+)	53 bp
Tssr78960	Chr8:95747069-95747080 (+)	2,755 bp
Tssr78961	Chr8:95747334-95747347 (+)	3,021 bp
Tssr78962	Chr8:95747379-95747390 (+)	3,065 bp
Tssr78963	Chr8:95747417-95747447 (+)	3,112 bp
Tssr78964	Chr8:95747452-95747473 (+)	3,143 bp
Tssr78965	Chr8:95747502-95747519 (+)	3,191 bp
Tssr78966	Chr8:95747531-95747571 (+)	3,231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24