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Sh3glb1 Gene Detail
Summary
  • Symbol
    Sh3glb1
  • Name
    SH3-domain GRB2-like B1 (endophilin)
  • Synonyms
    Bif-1, Endophilin B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859730
    NCBI Gene: 54673
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:144389439-144426096 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 69.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    949 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859730
 protein coding gene Chr3:144389426-144426186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027952
 protein coding gene Chr3:147992007-148031663 (-)
A/J MGP_AJ_G0027909
 protein coding gene Chr3:142748098-142784756 (-)
AKR/J MGP_AKRJ_G0027875
 protein coding gene Chr3:146563896-146600458 (-)
BALB/cJ MGP_BALBcJ_G0027921
 protein coding gene Chr3:142542115-142582315 (-)
C3H/HeJ MGP_C3HHeJ_G0027651
 protein coding gene Chr3:146885478-146922093 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028365
 protein coding gene Chr3:153084234-153122206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025703
 protein coding gene Chr3:137882885-137920635 (-)
CAST/EiJ MGP_CASTEiJ_G0027107
 protein coding gene Chr3:146839800-146880582 (-)
CBA/J MGP_CBAJ_G0027628
 protein coding gene Chr3:158330227-158366739 (-)
DBA/2J MGP_DBA2J_G0027767
 protein coding gene Chr3:141907487-141944577 (-)
FVB/NJ MGP_FVBNJ_G0027734
 protein coding gene Chr3:139299401-139336435 (-)
LP/J MGP_LPJ_G0027877
 protein coding gene Chr3:149411853-149450318 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027766
 protein coding gene Chr3:166678004-166718116 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028423
 protein coding gene Chr3:146168426-146205080 (-)
PWK/PhJ MGP_PWKPhJ_G0026831
 protein coding gene Chr3:141713789-141751816 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026658
 protein coding gene Chr3:144328264-144365164 (-)
WSB/EiJ MGP_WSBEiJ_G0027186
 protein coding gene Chr3:147055664-147092460 (-)



Homology
more
  • Human Ortholog
    SH3GLB1, SH3 domain containing GRB2 like, endophilin B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3GLB1, SH3 domain containing GRB2 like, endophilin B1
  • Synonyms
    Bif-1, CGI-61, dJ612B15.2, PPP1R70
  • Links
    NCBI Gene ID: 51100
    neXtProt AC: NX_Q9Y371
    UniProt: Q9Y371

  • Chr Location
    1p22.3; chr1:86704570-86748184 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Endonuclease-mediated
    2
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Sh3glb1
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    19 strains or lines available
Homozygous mutation of this gene results in delayed apoptosis of embryonic fibroblasts in response to serum withdrawal or treatment with a mitochondrial stress inducer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    12
  • cDNA Data
    17
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037062 Ensembl Gene Model | MGI Sequence Detail 36658 C57BL/6J ±  kb
transcript ENSMUST00000199854 Ensembl | MGI Sequence Detail 1416 Not Applicable  
polypeptide ENSMUSP00000142716 Ensembl | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
less
MGI:2139573, MGI:2139664, MGI:2139863
References
more
  • Summaries
    All 55
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory