Crtam MGI Mouse Gene Detail - MGI:1859822 - cytotoxic and regulatory T cell molecule

Symbol

Crtam
Name

cytotoxic and regulatory T cell molecule
Synonyms

class I-restricted T cell-associated molecule

Feature Type

protein coding gene
IDs

MGI:1859822
NCBI Gene: 54698
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:40880987-40915922 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 21.79 cM
Mapping Data

4 experiments

SNPs within 2kb

1135 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859822	protein coding gene	Chr9:40880987-40915924 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034673	protein coding gene	Chr9:39225010-39256411 (-)
A/J	MGP_AJ_G0034653	protein coding gene	Chr9:38209129-38240568 (-)
AKR/J	MGP_AKRJ_G0034579	protein coding gene	Chr9:38929091-38960490 (-)
BALB/cJ	MGP_BALBcJ_G0034644	protein coding gene	Chr9:37950941-37982400 (-)
C3H/HeJ	MGP_C3HHeJ_G0034355	protein coding gene	Chr9:39454037-39485455 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035167	protein coding gene	Chr9:40468066-40500373 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032080	protein coding gene	Chr9:37834754-37866121 (-)
CAST/EiJ	MGP_CASTEiJ_G0033678	protein coding gene	Chr9:39183013-39215866 (-)
CBA/J	MGP_CBAJ_G0034328	protein coding gene	Chr9:41855994-41887383 (-)
DBA/2J	MGP_DBA2J_G0034487	protein coding gene	Chr9:38140877-38173085 (-)
FVB/NJ	MGP_FVBNJ_G0034427	protein coding gene	Chr9:37364858-37396490 (-)
LP/J	MGP_LPJ_G0034568	protein coding gene	Chr9:39496186-39527594 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034471	protein coding gene	Chr9:43905295-43944866 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035186	protein coding gene	Chr9:38852884-38884303 (-)
PWK/PhJ	MGP_PWKPhJ_G0033383	protein coding gene	Chr9:37953476-37985835 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033219	protein coding gene	Chr9:39085834-39116943 (-)
WSB/EiJ	MGP_WSBEiJ_G0033791	protein coding gene	Chr9:38879364-38911811 (-)

Human Ortholog

CRTAM, cytotoxic and regulatory T cell molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRTAM, cytotoxic and regulatory T cell molecule
Synonyms

CD355
Links

HGNC:24313

NCBI Gene ID: 56253

neXtProt AC: NX_O95727

UniProt: O95727
Chr Location

11q24.1; chr11:122838500-122872643 (+) GRCh38

MGI Vertebrate Homology

Crtam stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CRTAM
Gene Tree

Crtam

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Homozygous null mice have defects in late stage T cell activation that leads to less production of inflammatory cytokines, higher proliferation, and an increase in T cell number with age.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS40593.2, CCDS72216.1

Ensembl

ENSMUSG00000032021 (Evidence)
NCBI Gene

54698

			Length	Strain/Species	Flank
genomic	54698	NCBI Gene Model \| MGI Sequence Detail	34936	C57BL/6J	± kb
transcript	NM_001281954	RefSeq \| MGI Sequence Detail	5044	ZRU/MplStud
polypeptide	Q149L7	UniProt \| EBI \| MGI Sequence Detail	393	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005899 cytotoxic and regulatory T-cell molecule

(term hierarchy)
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR053096 Cytotoxic and regulatory T-cell molecule

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q149L7 2 sites

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All nucleic 11

Genomic 2

cDNA 7

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 12
Earliest

J:62065 Kennedy J, et al., A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol. 2000 May;67(5):725-34
Latest

J:299768 Vazquez-Martinez JA, et al., Short Disordered Epitope of CRTAM Ig-Like V Domain as a Potential Target for Blocking Antibodies. Int J Mol Sci. 2020 Nov 20;21(22):8798

TSS for Crtam:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88983	Chr9:40915991-40916010 (-)	-79 bp
Tssr88982	Chr9:40915895-40915928 (-)	10 bp
Tssr88981	Chr9:40915858-40915869 (-)	58 bp
Tssr88980	Chr9:40905887-40905913 (-)	10,022 bp
Tssr88979	Chr9:40905869-40905885 (-)	10,045 bp
Tssr88978	Chr9:40895797-40895798 (-)	20,124 bp
Tssr88977	Chr9:40895784-40895796 (-)	20,132 bp
Tssr88976	Chr9:40895775-40895783 (-)	20,143 bp
Tssr88975	Chr9:40895756-40895770 (-)	20,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24