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Hes6 Gene Detail
Summary
  • Symbol
    Hes6
  • Name
    hairy and enhancer of split 6
  • Synonyms
    bHLHb41
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859852
    NCBI Gene: 55927
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91339205-91341760 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859852
 protein coding gene Chr1:91339204-91342901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016309
 protein coding gene Chr1:92953732-92956287 (-)
A/J MGP_AJ_G0016290
 protein coding gene Chr1:89605444-89607999 (-)
AKR/J MGP_AKRJ_G0016251
 protein coding gene Chr1:92266699-92269254 (-)
BALB/cJ MGP_BALBcJ_G0016246
 protein coding gene Chr1:89791628-89794183 (-)
C3H/HeJ MGP_C3HHeJ_G0016075
 protein coding gene Chr1:92487776-92490331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016705
 protein coding gene Chr1:96515904-96518459 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014423
 protein coding gene Chr1:83863487-83866071 (-)
CAST/EiJ MGP_CASTEiJ_G0015660
 protein coding gene Chr1:91832134-91834696 (-)
CBA/J MGP_CBAJ_G0016051
 protein coding gene Chr1:99602872-99605427 (-)
DBA/2J MGP_DBA2J_G0016154
 protein coding gene Chr1:88836628-88839183 (-)
FVB/NJ MGP_FVBNJ_G0016153
 protein coding gene Chr1:87867254-87869809 (-)
LP/J MGP_LPJ_G0016225
 protein coding gene Chr1:94126691-94129246 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016178
 protein coding gene Chr1:102845429-102847984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016745
 protein coding gene Chr1:92291044-92293599 (-)
PWK/PhJ MGP_PWKPhJ_G0015444
 protein coding gene Chr1:88250569-88253124 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015227
 protein coding gene Chr1:91213209-91215760 (-)
WSB/EiJ MGP_WSBEiJ_G0015718
 protein coding gene Chr1:92088768-92091323 (-)



Homology
more
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
  • Synonyms
    bHLHb41, bHLHc23, C-HAIRY1, HES-6
  • Links
    NCBI Gene ID: 55502
    neXtProt AC: NX_Q96HZ4
    UniProt: Q96HZ4

  • Chr Location
    2q37.3; chr2:238238267-238240662 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1377
  • Tissues
    379
  • cDNA Data
    83
  • Literature Summary
    56
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067071 Ensembl Gene Model | MGI Sequence Detail 2556 C57BL/6J ±  kb
transcript ENSMUST00000086851 Ensembl | MGI Sequence Detail 1335 Not Applicable  
polypeptide ENSMUSP00000084062 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 85
    Primer pair 6
    Other 5

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138216
References
more
  • Summaries
    All 95
    Developmental Gene Expression 56
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:339600 Hermosilla Aguayo V, et al., ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory