Rcor2 MGI Mouse Gene Detail - MGI:1859854

Symbol

Rcor2
Name

REST corepressor 2
Synonyms

1A13, CoREST

Feature Type

protein coding gene
IDs

MGI:1859854
NCBI Gene: 104383
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:7244759-7252590 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.32 cM
Mapping Data

2 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859854	protein coding gene	Chr19:7244690-7252590 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024788	protein coding gene	Chr19:4389938-4397844 (+)
A/J	MGP_AJ_G0024755	protein coding gene	Chr19:4040952-4048858 (+)
AKR/J	MGP_AKRJ_G0024728	protein coding gene	Chr19:4171250-4179156 (+)
BALB/cJ	MGP_BALBcJ_G0024755	protein coding gene	Chr19:4154815-4162721 (+)
C3H/HeJ	MGP_C3HHeJ_G0024522	protein coding gene	Chr19:4301437-4310196 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025201	protein coding gene	Chr19:4478686-4486592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022635	protein coding gene	Chr19:3946093-3954050 (+)
CAST/EiJ	MGP_CASTEiJ_G0023995	protein coding gene	Chr19:4205698-4213573 (+)
CBA/J	MGP_CBAJ_G0024495	protein coding gene	Chr19:4555361-4564034 (+)
DBA/2J	MGP_DBA2J_G0024622	protein coding gene	Chr19:4008583-4014534 (+)
FVB/NJ	MGP_FVBNJ_G0024587	protein coding gene	Chr19:4044060-4052026 (+)
LP/J	MGP_LPJ_G0024708	protein coding gene	Chr19:4241192-4248524 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024617	protein coding gene	Chr19:4446219-4454125 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025249	protein coding gene	Chr19:4315823-4323729 (+)
PWK/PhJ	MGP_PWKPhJ_G0023741	protein coding gene	Chr19:4056437-4064377 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023545	protein coding gene	Chr19:4121180-4128451 (+)
WSB/EiJ	MGP_WSBEiJ_G0024057	protein coding gene	Chr19:4215943-4225635 (+)

Human Ortholog

RCOR2, REST corepressor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCOR2, REST corepressor 2
Links

HGNC:27455

NCBI Gene ID: 283248

neXtProt AC: NX_Q8IZ40

UniProt: Q8IZ40
Chr Location

11q13.1; chr11:63911230-63927762 (-) GRCh38

MGI Vertebrate Homology

Rcor2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCOR2
Gene Tree

Rcor2

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Endonuclease-mediated

4
Gene trapped

30
Targeted

6
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for neuronal specific conditional loss of expression display impaired neurogenesis and neuronal precursor cell proliferation resulting in a thin cerebral cortex.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1060
Tissues

171
cDNA Data

37
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcor2

ZFIN rcor2

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All Sequences

46
RefSeq

8
UniProt

3
CCDS

CCDS29522.2

Ensembl

ENSMUSG00000024968 (Evidence)
NCBI Gene

104383

			Length	Strain/Species	Flank
genomic	104383	NCBI Gene Model \| MGI Sequence Detail	7832	C57BL/6J	± kb
transcript	NM_001320554	RefSeq \| MGI Sequence Detail	2840	Not Specified
polypeptide	Q8C796	UniProt \| EBI \| MGI Sequence Detail	523	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013842 REST corepressor 2

(term hierarchy)
InterPro Domains

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR049048 REST corepressor, helical domain

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR051066 Transcriptional Regulator and Corepressor

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All nucleic 41

cDNA 38

Primer pair 3

Microarray probesets 3

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MGI:2147708

Summaries

All 68

Developmental Gene Expression 20

Gene Ontology 5

Phenotypes 15
Earliest

J:61357 Grimes JA, et al., The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J Biol Chem. 2000 Mar 31;275(13):9461-7
Latest

J:350990 Rummukainen P, et al., The complex role of Rcor2: Regulates mesenchymal stromal cell differentiation in vitro but is dispensable in vivo. Bone. 2024 Jun 27;187:117180

TSS for Rcor2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154741	Chr19:7245559-7245577 (+)	809 bp
Tssr154742	Chr19:7245600-7245659 (+)	871 bp
Tssr154743	Chr19:7245661-7245678 (+)	911 bp
Tssr154744	Chr19:7246078-7246097 (+)	1,329 bp
Tssr154745	Chr19:7247500-7247520 (+)	2,751 bp
Tssr154746	Chr19:7251807-7251818 (+)	7,054 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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