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Ppt2 Gene Detail
Summary
  • Symbol
    Ppt2
  • Name
    palmitoyl-protein thioesterase 2
  • Synonyms
    0610007M19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860075
    NCBI Gene: 54397
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34835636-34847484 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860075
 protein coding gene Chr17:34835636-34856993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023583
 protein coding gene Chr17:34695414-34707189 (-)
A/J MGP_AJ_G0023545
 protein coding gene Chr17:33515010-33526563 (-)
AKR/J MGP_AKRJ_G0023510
 protein coding gene Chr17:33931559-33944682 (-)
BALB/cJ MGP_BALBcJ_G0023549
 protein coding gene Chr17:33662434-33674410 (-)
C3H/HeJ MGP_C3HHeJ_G0023309
 protein coding gene Chr17:34325939-34338759 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023989
 protein coding gene Chr17:36011099-36030999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021468
 protein coding gene Chr17:31402967-31415117 (-)
CAST/EiJ MGP_CASTEiJ_G0022809
 protein coding gene Chr17:34397657-34410430 (-)
CBA/J MGP_CBAJ_G0023287
 protein coding gene Chr17:37545042-37556790 (-)
DBA/2J MGP_DBA2J_G0023415
 protein coding gene Chr17:32804941-32816820 (-)
FVB/NJ MGP_FVBNJ_G0023382
 protein coding gene Chr17:32708839-32720958 (-)
LP/J MGP_LPJ_G0023493
 protein coding gene Chr17:34966551-34980238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023405
 protein coding gene Chr17:36430888-36444737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024032
 protein coding gene Chr17:34242211-34253761 (-)
PWK/PhJ MGP_PWKPhJ_G0022557
 protein coding gene Chr17:31733930-31745786 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022374
 protein coding gene Chr17:32227094-32239225 (-)
WSB/EiJ MGP_WSBEiJ_G0022870
 protein coding gene Chr17:34333548-34348548 (-)



Homology
more
  • Human Ortholog
    PPT2, palmitoyl-protein thioesterase 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPT2, palmitoyl-protein thioesterase 2
  • Synonyms
    C6orf8, G14, PPT-2
  • Links
    NCBI Gene ID: 9374
    neXtProt AC: NX_Q9UMR5
    UniProt: Q9UMR5

  • Chr Location
    6p21.32; chr6:32153441-32163678 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppt2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show autofluorescent storage material in brain, abnormal clasping behavior, spasticity, ataxia and increased adult mortality. In addition, lipofuscin pigments in pancreas, bone marrow histiocytosis and splenomegaly are observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    126
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015474 Ensembl Gene Model | MGI Sequence Detail 11849 C57BL/6J ±  kb
    transcript ENSMUST00000166040 Ensembl | MGI Sequence Detail 1139 Not Applicable  
    polypeptide ENSMUSP00000132006 Ensembl | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 8

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1918916, MGI:2146778
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory