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Ubqln1 Gene Detail
Summary
  • Symbol
    Ubqln1
  • Name
    ubiquilin 1
  • Synonyms
    1110046H03Rik, 1810030E05Rik, D13Ertd372e, DA41, Dsk2, Plic-1, XDRP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860276
    NCBI Gene: 56085
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:58323970-58363467 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    837 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860276
 protein coding gene Chr13:58323970-58363467 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020629
 protein coding gene Chr13:57803111-57842575 (-)
A/J MGP_AJ_G0020583
 protein coding gene Chr13:55657464-55696868 (-)
AKR/J MGP_AKRJ_G0020561
 protein coding gene Chr13:57318019-57357434 (-)
BALB/cJ MGP_BALBcJ_G0020579
 protein coding gene Chr13:55907847-55947536 (-)
C3H/HeJ MGP_C3HHeJ_G0020378
 protein coding gene Chr13:57125891-57165332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021013
 protein coding gene Chr13:59583123-59622547 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018595
 protein coding gene Chr13:53562552-53600889 (-)
CAST/EiJ MGP_CASTEiJ_G0019892
 protein coding gene Chr13:57245656-57290114 (-)
CBA/J MGP_CBAJ_G0020338
 protein coding gene Chr13:61829659-61869007 (-)
DBA/2J MGP_DBA2J_G0020461
 protein coding gene Chr13:55198989-55238629 (-)
FVB/NJ MGP_FVBNJ_G0020440
 protein coding gene Chr13:54686747-54725987 (-)
LP/J MGP_LPJ_G0020537
 protein coding gene Chr13:58076139-58120649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020469
 protein coding gene Chr13:61197390-61238433 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021056
 protein coding gene Chr13:56917657-56957016 (-)
PWK/PhJ MGP_PWKPhJ_G0019648
 protein coding gene Chr13:55200439-55241456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019475
 protein coding gene Chr13:55828081-55868684 (-)
WSB/EiJ MGP_WSBEiJ_G0019954
 protein coding gene Chr13:57359676-57399466 (-)



Homology
more
  • Human Ortholog
    UBQLN1, ubiquilin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBQLN1, ubiquilin 1
  • Synonyms
    DA41, DSK2, PLIC-1, UBQN, XDRP1
  • Links
    NCBI Gene ID: 29979
    neXtProt AC: NX_Q9UMX0
    UniProt: Q9UMX0

  • Chr Location
    9q22; chr9:83659968-83707958 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null animals display impaired degradation of ubiquitinated proteins in the brain, increased ischemia/reperfusion-caused brain injury, and slower functional recovery after injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    258
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56085 NCBI Gene Model | MGI Sequence Detail 39498 C57BL/6J ±  kb
    transcript NM_026842 RefSeq | MGI Sequence Detail 3693 ZRU/MplStud  
    polypeptide Q8R317 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 259
      cDNA 258
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196410, MGI:1916055, MGI:1917327, MGI:2145351, MGI:2145489
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory