Apba1 MGI Mouse Gene Detail - MGI:1860297 - amyloid beta precursor protein binding family A member 1

Symbol

Apba1
Name

amyloid beta precursor protein binding family A member 1
Synonyms

6430513E09Rik, Lin-10, Mint, Mint1, X11, X11alpha

Feature Type

protein coding gene
IDs

MGI:1860297
NCBI Gene: 319924
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:23736251-23926960 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 18.45 cM
Mapping Data

1 experiment

SNPs within 2kb

6386 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860297	protein coding gene	Chr19:23736170-23926961 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024990	protein coding gene	Chr19:21934072-22133559 (+)
A/J	MGP_AJ_G0024967	protein coding gene	Chr19:20733084-20925417 (+)
AKR/J	MGP_AKRJ_G0024937	protein coding gene	Chr19:21532352-21727886 (+)
BALB/cJ	MGP_BALBcJ_G0024966	protein coding gene	Chr19:20771386-20966202 (+)
C3H/HeJ	MGP_C3HHeJ_G0024723	protein coding gene	Chr19:21477167-21675909 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025407	protein coding gene	Chr19:22626416-22832552 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022826	protein coding gene	Chr19:20911732-21104073 (+)
CAST/EiJ	MGP_CASTEiJ_G0024192	protein coding gene	Chr19:21214939-21415465 (+)
CBA/J	MGP_CBAJ_G0024701	protein coding gene	Chr19:23609242-23833475 (+)
DBA/2J	MGP_DBA2J_G0024833	protein coding gene	Chr19:20739846-20934179 (+)
FVB/NJ	MGP_FVBNJ_G0024794	protein coding gene	Chr19:20602075-20798389 (+)
LP/J	MGP_LPJ_G0024917	protein coding gene	Chr19:21879912-22084574 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024821	protein coding gene	Chr19:23673451-23878726 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025462	protein coding gene	Chr19:21514467-21722570 (+)
PWK/PhJ	MGP_PWKPhJ_G0023940	protein coding gene	Chr19:20331635-20531115 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023745	protein coding gene	Chr19:20745406-20976432 (+)
WSB/EiJ	MGP_WSBEiJ_G0024259	protein coding gene	Chr19:21548878-21745982 (+)

Human Ortholog

APBA1, amyloid beta precursor protein binding family A member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APBA1, amyloid beta precursor protein binding family A member 1
Synonyms

D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA
Links

HGNC:578

NCBI Gene ID: 320

neXtProt AC: NX_Q02410

UniProt: Q02410
Chr Location

9q21.12; chr9:69427532-69673013 (-) GRCh38

MGI Vertebrate Homology

Apba1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: APBA1
Gene Tree

Apba1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Animals carrying a homozygous mutation of this gene have reduced body size.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

21
cDNA Data

64
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA APBA1

Xenbase apba1

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All Sequences

50
RefSeq

12
UniProt

3
CCDS

CCDS50407.1

Ensembl

ENSMUSG00000024897 (Evidence)
NCBI Gene

319924

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024897	Ensembl Gene Model \| MGI Sequence Detail	190710	C57BL/6J	± kb
transcript	ENSMUST00000025830	Ensembl \| MGI Sequence Detail	6620	Not Applicable
polypeptide	ENSMUSP00000025830	Ensembl \| MGI Sequence Detail	842	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004115 amyloid-beta A4 precursor protein-binding family A member 1

(term hierarchy)
PDB

6LNM
InterPro Domains

IPR051230 Amyloid-beta A4 Precursor Protein-Binding

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain

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All nucleic 65

cDNA 64

Primer pair 1

Microarray probesets 4

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MGI:2442991

Summaries

All 49

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 13
Earliest

J:62652 Borg JP, et al., Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem. 1998 Nov 27;273(48):31633-6
Latest

J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8

TSS for Apba1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155599	Chr19:23736156-23736171 (+)	-87 bp
Tssr155600	Chr19:23736183-23736271 (+)	-24 bp
Tssr155601	Chr19:23736348-23736362 (+)	104 bp
Tssr155602	Chr19:23736376-23736389 (+)	132 bp
Tssr155603	Chr19:23822970-23822973 (+)	86,721 bp
Tssr155604	Chr19:23834549-23834554 (+)	98,301 bp
Tssr155605	Chr19:23870849-23870866 (+)	134,607 bp
Tssr155606	Chr19:23870870-23870900 (+)	134,634 bp
Tssr155607	Chr19:23870905-23870917 (+)	134,660 bp
Tssr155608	Chr19:23870953-23870973 (+)	134,712 bp
Tssr155609	Chr19:23881941-23881947 (+)	145,693 bp
Tssr155610	Chr19:23881953-23881996 (+)	145,724 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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